PF 04217903 mesylate

PF 04217903 mesylate Chemische Eigenschaften,Einsatz,Produktion Methoden

• Verwenden

  PF 04217903 is highly selective, high affinity c-Met inhibitor (Ki = 6-7 nM against wild type c-Met). Displays >1000-fold selectivity for c-Met over a panel of 208 kinases.

• Biologische Aktivität

  PF-04217903 is a highly selective, potent inhibitor of the hepatocyte growth factor receptor c-Met. PF-04217903 inhibits endogenous, wild type c-Met in A549 human lung carcinoma cells with an IC50 of 4.8 nM. The compund displays 1000-fold selectivity against a panel of 208 other kinases.', 'PF-04217903 is an ATP-competitive inhibitor. It elicits antiangiogenic functionality. PF-04217903 inhibits c-Met phosphorylation in xenograft models leading to partial tumor growth suppression.

• Lager

  Store at +4°C

PF 04217903 mesylate Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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