COG 133 Struktur

COG 133

Bezeichnung:COG 133

CAS-Nr514200-66-9

Englisch Name:COG 133

CBNumberCB92518926

SummenformelC97H181N37O19

Molgewicht2169.71

MOL-Datei514200-66-9.mol

COG 133 physikalisch-chemischer Eigenschaften

storage temp.	-20°C
Löslichkeit	H2O: >1mg/mL
Aggregatzustand	lyophilized
Farbe	white
Wasserlöslichkeit	Soluble to 1 mg/ml in water

Sicherheit

WGK Germany

COG 133 Chemische Eigenschaften,Einsatz,Produktion Methoden

Biologische Aktivität
cog 133, (c97h181n37o19), a peptide with the sequence ac-leu-arg-val-arg-leu-ala-ser-his-leu-arg-lys-leu-arg-lys-arg-leu-leu-amide,mw= 2169.73.apolipoprotein e (apoe) is 299 amino acids long and transports lipoproteins(1), fat-soluble vitamins, and cholesterol into the lymph system and then into the blood. it is synthesized principally in the liver, but has also been found in other tissues such as the brain, kidneys, and spleen. in the nervous system, non-neuronal cell types, most notably astroglia and microglia, are the primary producers of apoe, while neurons preferentially express the receptors for apoe. there are seven currently identified mammalian receptors for apoe which belong to the evolutionarily conserved low density lipoprotein receptor gene family.apoe was initially recognized for its importance in lipoprotein metabolism and cardiovascular disease(2). defects in apoe result in familial dysbetalipoproteinemia aka type iii hyperlipoproteinemia (hlp iii), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron, vldl and ldl remnants[citation needed]. more recently, it has been studied for its role in several biological processes not directly related to lipoprotein transport, including alzheimer's disease (ad), immunoregulation, and cognition(3).figure1 the structures of apolipoprotein e (apoe) cog 133figure2 potential roles of apoe in neurons and alzheimer's disease
Lager
Store at -20°C
Einzelnachweise
1. Singh PP, Singh M, Mastana SS (2002). "Genetic variation of apolipoproteins in North Indians". Hum. Biol. 74 (5): 673–82.2. van den Elzen P, Garg S, León L, Brigl M, Leadbetter EA, Gumperz JE, Dascher CC, Cheng TY, Sacks FM, Illarionov PA, Besra GS, Kent SC, Moody DB, BrennerMB. (2005). "Apolipoprotein-mediated pathways of lipid antigen presentation.". Nature 437 (7060): 906-10.3. Zhang HL, Wu J, Zhu J (2010). "The Role of Apolipoprotein E in Guillain-Barré Syndrome and Experimental Autoimmune Neuritis". J. Biomed. Biotechnol. 2010: 357412.

COG 133 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

514200-66-9, COG 133 Verwandte Suche:

Send Inquriy