3--Phenyl-N-(2,2,2-trichloro-1-((((4-chlorophenyl)amino)carbonothioyl)amino)ethyl)acrylamide Struktur

3--Phenyl-N-(2,2,2-trichloro-1-((((4-chlorophenyl)amino)carbonothioyl)amino)ethyl)acrylamide

Bezeichnung:3--Phenyl-N-(2,2,2-trichloro-1-((((4-chlorophenyl)amino)carbonothioyl)amino)ethyl)acrylamide

Englisch Name:3--Phenyl-N-(2,2,2-trichloro-1-((((4-chlorophenyl)amino)carbonothioyl)amino)ethyl)acrylamide

CBNumberCB92518799

SummenformelC18H15Cl4N3OS

Molgewicht463.21

3--Phenyl-N-(2,2,2-trichloro-1-((((4-chlorophenyl)amino)carbonothioyl)amino)ethyl)acrylamide physikalisch-chemischer Eigenschaften

storage temp.	2-8°C
Löslichkeit	DMSO: ≥10mg/mL
Aggregatzustand	powder
Farbe	white to off-white

Sicherheit

Kennzeichnung gefährlicher	N
R-Sätze:	50/53
S-Sätze:	60-61
RIDADR	UN 3077 9 / PGIII
WGK Germany	3

Gefahreninformationscode (GHS)

3--Phenyl-N-(2,2,2-trichloro-1-((((4-chlorophenyl)amino)carbonothioyl)amino)ethyl)acrylamide Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden
Sal003 was used to study the role of eIF2α in Subtilase cytotoxin-induced apoptosis in HeLa cells.
Biologische Aktivität
eukaryotic initiation factor 2 α-subunit (eif2α) plays a critical role in the regulation of protein synthesis. moreover, it also plays an important role in synaptic plasticity and long-term memory consolidation. sal003 is a selective inhibitor of eif2α dephosphorylation.
Biochem/physiol Actions
Sal003 inhibits the late long-term potentiation (L-LTP) and long-term memory formation in mammalian hippocampal slices. The effect of Sal003 on L-LTP is mediated by the transcription factor, ATF4.
in vitro
sal003 specifically prevents dephosphorylation of eif2α by blocking eif2α phosphatases. in sal003-treated cells polysomes dissociated and consistent with this β-actin mrna shifted to lighter fractions, reflecting the inhibition of general translation [1].
in vivo
intra-basolateral amygdala (bla) infusions of sal003 immediately after memory retrieval disrupted the reconsolidation of morphine- or cocaine-induced cpp, leading to a long-lasting suppression of drug-paired stimulus-induced craving. moreover, inhibition of eif2α dephosphorylation in the bla immediately after light/tone stimulus retrieval decreased subsequent cue-induced heroin-seeking behavior in the self-administration procedure. these results demonstrate that eif2α dephosphorylation in the bla mediates the memory reconsolidation of drug-paired stimuli [1].
Lager
Store at -20°C
Einzelnachweise
[1] jian m, luo yx, xue yx, han y, shi hs, liu jf, yan w, wu p, meng sq, deng jh, shen hw, shi j, lu l. eif2α dephosphorylation in basolateral amygdala mediates reconsolidation of drug memory. j neurosci. 2014;34(30):10010-21.

3--Phenyl-N-(2,2,2-trichloro-1-((((4-chlorophenyl)amino)carbonothioyl)amino)ethyl)acrylamide Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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