Abacavir 5’-(2,3,4-Tri-O-isobytyryl)-β-D-glucuronic Acid Methyl Ester

Abacavir 5’-(2,3,4-Tri-O-isobytyryl)-β-D-glucuronic Acid Methyl Ester Chemische Eigenschaften,Einsatz,Produktion Methoden

• Chemische Eigenschaften

  Off-White Solid

• Verwenden

  Abacavir 5’-(2,3,4-Tri-O-isobytyryl)-β-D-glucuronic Acid Methyl Ester is an intermediate used in the synthesis of various Abacavir metabolites. Abacavir is a carbocyclic 2''-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.

• Verwenden

  An intermediate in the preparation of Abacavir metabolites

Abacavir 5’-(2,3,4-Tri-O-isobytyryl)-β-D-glucuronic Acid Methyl Ester Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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