Amino-PEG4-acid Struktur

Amino-PEG4-acid

Bezeichnung:Amino-PEG4-acid

CAS-Nr663921-15-1

Englisch Name:Amino-PEG4-acid

CBNumberCB92501434

SummenformelC11H23NO6

Molgewicht265.3

MOL-Datei663921-15-1.mol

Amino-PEG4-acid physikalisch-chemischer Eigenschaften

Siedepunkt	409.6±40.0 °C(Predicted)
Dichte	1.134±0.06 g/cm3(Predicted)
storage temp.	2-8°C
pka	4.28±0.10(Predicted)
Aggregatzustand	powder
Farbe	White
InChI	InChI=1S/C11H23NO6/c12-2-4-16-6-8-18-10-9-17-7-5-15-3-1-11(13)14/h1-10,12H2,(H,13,14)
InChIKey	DKUZHSDZSMQOGQ-UHFFFAOYSA-N
SMILES	C(O)(=O)CCOCCOCCOCCOCCN

Sicherheit

HS Code

2942000090

Gefahreninformationscode (GHS)

Amino-PEG4-acid Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
Amino-PEG4-acid is a very popular PEG linker. The amino group (NH2) is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The terminal carboxylic acid can react with primary amine groups of activated NHS ester to form a stable amide bond, long PEG spacer increases reagent's solubility in aqueous media.
Verwenden
H2N-Dpeg(4)-COOH, can be used in optical imaging of integrin αvβ3 expression with near-infrared fluorescent RGD dimer with tetra(ethylene glycol) linkers. Integrin αvβ3 plays great roles in tumor angiogenesis, invasion, and metastasis.
benefits
Amino-dPEG4-acid has a primary amine and propionic acid terminating opposite ends of a 16-atoms long (18.0 ?) polyethylene glycol (PEG) spacer. The single molecular weight PEG spacer is discrete (D = 1). Moreover, it is highly hydrophilic, and it imparts hydrophilicity to conjugates that incorporate it. Amino-dPEG4-acid is useful in many different applications, including peptide synthesis, surface modification, dendrimer construction, and small molecule modification.
reaction suitability
reaction type: Pegylations
Einzelnachweise
1. Improving tumor-targeting capability and pharmacokinetics of (99m)Tc-labeled cyclic RGD dimers with PEG(4) linkers. DOI:10.1021/mp800150r
2. Short PEG-linkers improve the performance of targeted, activatable monoclonal antibody-indocyanine green optical imaging probes. DOI:10.1021/bc400050k
3. Microwave-mediated synthesis of labeled nucleotides with utility in the synthesis of DNA probes. DOI:10.1021/bc100013b
4. Improving tumor uptake and pharmacokinetics of (64)Cu-labeled cyclic RGD peptide dimers with Gly(3) and PEG(4) linkers. DOI:10.1021/bc800455p

Amino-PEG4-acid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

663921-15-1, Amino-PEG4-acid Verwandte Suche:

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