Aviptadil

Bezeichnung:Aviptadil

CAS-Nr40077-57-4

Englisch Name:Aviptadil

CBNumberCB9215069

SummenformelC147H238N44O42S

Molgewicht3325.8

MOL-Datei40077-57-4.mol

Aviptadil physikalisch-chemischer Eigenschaften

Dichte	1.47±0.1 g/cm3(Predicted)
storage temp.	−20°C
Löslichkeit	1% acetic acid: soluble 0.1%, clear, colorless
Aggregatzustand	powder
Wasserlöslichkeit	Soluble to 1 mg/ml in water
Sequenz	His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn-NH2
InChIKey	HEOYHMUESMJFDC-RIWXPGAOSA-N

Sicherheit

WGK Germany

Aviptadil Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden
Pulmonary hypertension;Erectile dysfunction
Verwenden
Vasoactive Intestinal Peptide human, porcine, rat has been used as an immunogen to analyze the immunohistochemical reactions. It has also been used in cell migration assay.
Allgemeine Beschreibung
Vasoactive intestinal peptide (VIP) is widely distributed inthe body and is believed to occur throughout the gastrointestinaltract. It is a 28-residue polypeptide with structuralsimilarities to secretin and glucagon. It causes vasodilatationand increases cardiac contractibility. VIP stimulates bicarbonatesecretion, relaxes gastrointestinal and othersmooth muscles, stimulates glycogenesis, inhibits gastricacid secretion, and stimulates insulin secretion. Its hormonaland neurotransmitter role has been investigated.
Biochem/physiol Actions
VIP (Vasoactive intestinal peptide) possesses anti-inflammatory and immunomodulatory functions. It controls the pathogenesis of rheumatoid arthritis. It is also involved in neuroblastoma differentiation, and pancreatic insulin secretion. Vip exhibits its function through G-protein coupled receptors. Some of the other important actions of VIP is associated with the digestive, respiratory, cardiovascular and reproductive systems.
Clinical Use
28-peptide that is structurally related to secretin and glucagon. It has a diverse biological actions. It has orphan drug status for the treatment of acute esophageal food impaction.
Clinical Use
Several clinical trials have been reported regarding the use of VIP or its analog for asthma and sarcoidosis. In an open clinical Phase II study, patients with histologically proven sarcoidosis and active disease were treated with nebulized VIP. VIP inhalation was safe and well tolerated, and significantly reduced the production of tumor necrosis factor-α by cells isolated from the bronchoalveolar lavage fluids of these patients.
Lager
Store at -20°C

Aviptadil Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Send Inquriy