CYCLOPIAZONIC ACID Struktur

CYCLOPIAZONIC ACID

Bezeichnung:CYCLOPIAZONIC ACID

CAS-Nr18172-33-3

Englisch Name:CYCLOPIAZONIC ACID

CBNumberCB9207176

SummenformelC20H20N2O3

Molgewicht336.38

MOL-Datei18172-33-3.mol

CYCLOPIAZONIC ACID physikalisch-chemischer Eigenschaften

Schmelzpunkt	245-246°C
Siedepunkt	472.86°C (rough estimate)
Dichte	1.2171 (rough estimate)
Brechungsindex	1.5700 (estimate)
storage temp.	-20°C
Löslichkeit	DMSO: soluble
Aggregatzustand	powder
pka	4.50±1.00(Predicted)
Farbe	white to off-white
Wasserlöslichkeit	Soluble in DMSO (100 mM), ethanol (5 mM), DMF (~20 mg/ml), and 1:1 DMSO:PBS(pH 7.2) (0.5 mg/ml). Insoluble in water.
EPA chemische Informationen	Cyclopiazonic acid (18172-33-3)

Sicherheit

Kennzeichnung gefährlicher	T
R-Sätze:	25
S-Sätze:	36/37/39-45
RIDADR	UN 2811 6.1/PG 2
WGK Germany	3
RTECS-Nr.	UY8587000
HazardClass	6.1(a)
PackingGroup	II
HS Code	29337900
Giftige Stoffe Daten	18172-33-3(Hazardous Substances Data)
Toxizität	chicken,LD50,oral,12mg/kg (12mg/kg),Poultry Science. Vol. 65(Suppl,

Gefahreninformationscode (GHS)

CYCLOPIAZONIC ACID Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R25:Giftig beim Verschlucken.
S-Sätze Betriebsanweisung:
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
Beschreibung
Cyclopiazonic acid is a mycotoxin that has been found in Penicillium and Aspergillus and an inhibitor of sarcoplasmic/endoplasmic reticulum Ca²⁺-ATPase (SERCA; IC₅₀ = 0.6 μM). In vivo, cyclopiazonic acid (11-14 mg/kg) induces ptosis, hypothermia, tremor, and cachexia, as well as induces lethality (LD₅₀ = 13 mg/kg), in rats. It induces tachycardia and sedation in rabbits when administered at a dose of 10 mg/kg.
Chemische Eigenschaften
off-white powder or crystals
Verwenden
Cyclopiazonic acid from?Penicillium cyclopium has been used:
- as a standard in aflatoxin detection and quantification by thin layer chromatography (TLC)
- as a component in Ca²⁺-free DMEM/10% fetal bovine serum (FBS)
- as a reversible inhibitor of the sarco/endoplasmic reticulum Ca²⁺-ATPase (SERCA) to examine the role of luminal calcium in endoplasmic recticulum (ER)-to-Golgi trafficking
- as an endoplasmic reticulum Ca²⁺-ATPase blocker, to treat neurons and also to study the role of the endoplasmic reticulum (ER) in releasing and sustaining Ca²⁺?during Ca²⁺-induced Ca²⁺ release (CICR) to inhibit SERCA
Verwenden
The use of Cyclopiazonic acid on Langendorff-perfused murine hearts displayed anti-arrhythmic effects. Also, administration of cyclopiazonic acid on rat soleus muscle showed a decrease in hormone sensitive lipase activity and triacylglycerol hydrolysis. It is also used as an inhibitor of endoplasmic reticulum Ca2+-ATPase.
Verwenden
Cyclopiazonic acid is a tremorigenic indole produced by several species of Aspergillus and Penicillium. Cyclopiazonic acid is a highly specific inhibitor of calcium ATPase of sarcoplasmic reticulum, altering calcium homeostasis and ATP-dependent calcium transport and resulting in the release of intracellular stored Ca2+ without increasing IP3.
Allgemeine Beschreibung
Cyclopiazonic acid (CPA), a tetramic acid is synthesized by various Aspergillus and Penicillium species.
Biologische Aktivität
Cell-permeable, reversible inhibitor of sarcoplasmic reticulum Ca 2+ -ATPase.
Biochem/physiol Actions
Inhibits the sarcoplasmic reticulum Ca2+-pump.
Lager
-20°C

CYCLOPIAZONIC ACID Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

18172-33-3, CYCLOPIAZONIC ACID Verwandte Suche:

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