All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry.
The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit .
Allgemeine Beschreibung
Anti-p50 CDC37 Antibody detects endogenous levels of total p50 CDC37 protein.
Biochem/physiol Actions
Hsp90 co-chaperone Cdc37 is a protein encoded by the CDC37 gene in humans. It is identified as a start gene in budding yeast and is required for association of CDC28 with cyclins. It is an essential gene in Saccharomyces cerevisiae that interacts genetically with multiple protein kinases. It is a molecular chaperone that acts as a crucial element in the protein signaling pathway and for the production of Cdk4/cyclin D complexes. It is essential for maintaining prostate tumor cell growth and its up-regulation is a common early event in localized human prostate cancer. It also induces proliferation and is critical for survival in human prostate epithelial cells.
