SINEFUNGIN Struktur

SINEFUNGIN

Bezeichnung:SINEFUNGIN

CAS-Nr58944-73-3

Englisch Name:SINEFUNGIN

CBNumberCB9167377

SummenformelC15H23N7O5

Molgewicht381.39

MOL-Datei58944-73-3.mol

SINEFUNGIN physikalisch-chemischer Eigenschaften

alpha	D25 -2.61° (c = 5 in water); D23 +12 ±2° (c = 0.227 in water)
Siedepunkt	783.2±70.0 °C(Predicted)
Dichte	1.91±0.1 g/cm3(Predicted)
storage temp.	2-8°C
Löslichkeit	H₂O: soluble
Aggregatzustand	powder
pka	pKa (66% DMF): 2.9, 3.9, 8.9, 10.2(at 25℃)
Farbe	white to yellow
Biologische Quelle	rat
Stabilität	Stable for 2 years from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 1 month.

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	22
S-Sätze:	36
WGK Germany	3
RTECS-Nr.	HE3140000
HS Code	29419090
Toxizität	LD50 s.c. in mice: 185 mg/kg (Hamill, Hoehn, J. Antibiot.)

Gefahreninformationscode (GHS)

SINEFUNGIN Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
S-Sätze Betriebsanweisung:
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
Sinefungin (58944-73-3) is a nucleoside S-adenosyl-1-methionine analog. Potent, competitive methyltransferase (protein, DNA, and RNA methyltransferases) inhibitor.1,2?IC50?< 1.0 and 2.5 μM for PRMT1 and SET7/9, respectively.3?Sinefungin binds with greater affinity to the adenine-specific DNA methyltransferase M.TaqI than S-adenosyl-L-homocysteine.4?Inhibits biofilm formation by?Streptococcus pneumoniae.5
Verwenden
Sinefungin is a natural nucleoside analog of S-adenosylmethionine and inhibits Streptococcus pneumoniae biofilm growth. Its derivatives can be used as inhibitors and structure probes for human protein lysine methyltransferase SETD2.
Verwenden
Sinefungin, a polar nucleoside antifungal active with broad biological activity, was isolated from a number of species of Streptomyces in the early 1970s. Sinefungin acts by inhibiting a wide range of methyltransferases, including the methylation of bases in DNA and RNA which alters cytosine deamination and gene expression. Sinefungin is widely used as a bioprobe to block methyltransferase-dependent pathways.
Definition
ChEBI: An adenosine that is the the delta-(5'-adenosyl) derivative of ornithine.
Allgemeine Beschreibung
Chemical structure: nucleoside
Biochem/physiol Actions
Probable transcription factor. Plays a critical role in the control of immune response.
Einzelnachweise
1) Barbes?et al. (1990),?Effects of sinefungin and S-adenosylhomocysteine on DNA and protein methyltransferases from Streptomyces and other bacteria;? FEMS Microbiol. Lett.,?57?239 2) Yebra?et al. (1991),?The effect of sinefungin and synthetic analogues on RNA and DNA methyltransferases from Streptomyces;? J. Antibiot. (Tokyo),?44?1141 3) Cheng?et al. (2004),?Small molecule regulators of protein arginine methyltransferases;? J. Biol. Chem.,?279?23892 4) Schluckebier?et al. (1997), Differential binding of S-adenosylmethionine S-adenosylhomocysteine and Sinefungin to adenine-specific DNA methyltransferase M. TaqI;? J. Mol. Biol., 265?56 5) Yadav?et al. (2014),?Sinefungin, a natural nucleoside analogue of S-adenosylmethionine, inhibits Streptococcus pneumonia biofilm growth;? Biomed. Res. Int.,?2014?156987

SINEFUNGIN Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

58944-73-3, SINEFUNGIN Verwandte Suche:

Send Inquriy