1-O-Hexadecyl-2-O-acetyl-sn-glyce-ro-3-phosphocholin

Bezeichnung:1-O-Hexadecyl-2-O-acetyl-sn-glyce-ro-3-phosphocholin

CAS-Nr74389-68-7

Englisch Name:Platelet Activating Factor-16

CBNumberCB9143348

SummenformelC26H54NO7P

Molgewicht523.68

MOL-Datei74389-68-7.mol

Synonyma

1-O-Hexadecyl-2-O-acetyl-sn-glyce-ro-3-phosphocholin

1-O-Hexadecyl-2-O-acetyl-sn-glyce-ro-3-phosphocholin physikalisch-chemischer Eigenschaften

Schmelzpunkt	247 °C
storage temp.	-20°C
Löslichkeit	Soluble in H2O or ethanol
Aggregatzustand	lyophilized powder
Farbe	White to off-white
Wasserlöslichkeit	Soluble to 100 mM in water
BRN	3574588

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	22-38-40-48/20/22
S-Sätze:	36/37-24/25-22
RIDADR	UN 1888 6.1/PG 3
WGK Germany	3
RTECS-Nr.	EC6060000
F	10-21

Platelet Activating Factor-16 Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
R38:Reizt die Haut.
R40:Verdacht auf krebserzeugende Wirkung.
R48/20/22:Gesundheitsschädlich: Gefahr ernster Gesundheitsschäden bei längerer Exposition durch Einatmen und durch Verschlucken.
S-Sätze Betriebsanweisung:
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
S22:Staub nicht einatmen.
Verwenden
PAF (C16) (cas# 74389-68-7) is a blood platelet-activating factor, used to study human airway smooth muscle cell line.
Verwenden
C16-02:0 PC or 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine may be used as a substrate in enzymatic lipoprotein-associated phospholipase A2 (Lp-PLA2) activity assay. It may also be used to study its physicochemical properties and its interaction with peptides derived from the C-terminal domains of human apolipoprotein E.
Definition
ChEBI: A 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine betaine which has hexadecyl as the alkyl group. PAF is a potent phospholipid activator and mediator of many leukocyte functions, including platelet aggregation, inflammation, and anaphylaxis.
Allgemeine Beschreibung
C16-02:0 PC, also known as 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine (C16 PAF) (acetyl PAF), is a platelet-activating factor (PAF). Acetyl PAF is present in the body and it contains ether-linked hexadecyl chain at the sn-1 position and an acetyl group at the sn-2 position.
Biologische Aktivität
Endogenous platelet-activating factor (PAF) and ligand for PAF receptors. Produced by inflammatory cells and a potent chemoattractant for polymorphonuclear neutrophils. Induces increased vascular permeability.
Biochem/physiol Actions
Platelet-activating factor (PAF) is a pro-inflammatory agent that exhibits variety of biological and pharmacological effects. It plays a major role in initiation and progression of atherosclerosis. PAF acts as a potential biomarker for coronary artery diseases. It yields LysoPAF (1-O-alkyl-2-hydroxy-sn-glycero-3-phosphocholine) on hydrolysis by platelet-activating factor-acetylhydrolase.
Lager
Store at -20°C

1-O-Hexadecyl-2-O-acetyl-sn-glyce-ro-3-phosphocholin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

74389-68-7, Platelet Activating Factor-16 Verwandte Suche:

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