holomycin

holomycin Chemische Eigenschaften,Einsatz,Produktion Methoden

• Verwenden

  Holomycin-d3 is the isotope labelled analog of Holomycin (H458490); a member of the pyrrothine class of antibiotics that displays broad-spectrum antibacterial activity.

• Definition

  ChEBI: Holomycin is a dithiolopyrrolone antibiotic that is 4,5-dihydro[1,2]dithiolo[4,3-b]pyrrole in which the hydrogens at positions 5 and 6 have been replaced by oxo and acetamido groups, respectively. It is an inhibitor of DNA-dependent RNA polymerase, and exhibits antibacterial and antitumour properties. It has a role as a chelator, an antineoplastic agent, an EC 2.7.7.6 (RNA polymerase) inhibitor, an antibacterial agent, a marine metabolite and a bacterial metabolite. It is a dithiolopyrrolone antibiotic and a member of acetamides.

• Synthesis Reference(s)

  Journal of the American Chemical Society, 86, p. 5654, 1964 DOI: 10.1021/ja01078a049

holomycin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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