Limonin

Bezeichnung:Limonin

CAS-Nr1180-71-8

Englisch Name:Limonin

CBNumberCB9125063

SummenformelC26H30O8

Molgewicht470.51

MOL-Datei1180-71-8.mol

Limonin physikalisch-chemischer Eigenschaften

Schmelzpunkt	298 C
alpha	D -128° (c = 1.21 in acetone)
Siedepunkt	67 °C
Dichte	1.39±0.1 g/cm3(Predicted)
storage temp.	2-8°C
Löslichkeit	Chloroform (Slightly), DMSO (Sparingly)
Aggregatzustand	Solid
Farbe	White to Off-White
maximale Wellenlänge (λmax)	285nm(lit.)
Merck	14,5494
LogP	0.474 (est)
EPA chemische Informationen	Limonin (1180-71-8)

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	20/21/22
S-Sätze:	36-24/25
WGK Germany	3
RTECS-Nr.	RR1122000
HS Code	29321900

Gefahreninformationscode (GHS)

Limonin Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
S-Sätze Betriebsanweisung:
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
White powder
Verwenden
Limonin has been used:
- to treat human peripheral blood mononuclear cells (PBMCs) to test its effect on human immunodeficiency virus (HIV) replication
- to test its effects as an anti-osteoporosis agent in osteoblastogenesis activity in MC3T3-E1 cells and ovariectomized (OVX) rat model
- as a reference standard in high-performance liquid chromatography (HPLC) system
Verwenden
antiproliferative, antiviral, antiinflammatory, antinociceptive
Verwenden
Limonin is a limonoid extracted from various citrus plants. Bioactivity of Limonin have been revolved around its anti-HIV properties.
Definition
ChEBI: Limonin is a limonoid, an epoxide, a hexacyclic triterpenoid, a member of furans, an organic heterohexacyclic compound and a lactone. It has a role as a metabolite, an inhibitor and a volatile oil component.
Allgemeine Beschreibung
Limonin is a limonoid glycoside with cancer chemo-preventive activity.
Biochem/physiol Actions
Limonin is a triterpenoid aglycone that is a bitter principle of citrus fruits. It has anti-proliferative, proapoptotic activity on several cancer cell lines and inhibits azoxymethane-induced colon cancer in rats. It also inhibits HIV-1 replication in culturedf monocytes, macrophages, and mononuclear cells, perhaps by inhibition of HIV-1 protease activity.

Limonin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

1180-71-8, Limonin Verwandte Suche:

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