N-Hydroxynorborn-5-en-2,3-dicarboximid

Bezeichnung:N-Hydroxynorborn-5-en-2,3-dicarboximid

CAS-Nr21715-90-2

Englisch Name:N-Hydroxy-5-norbornene-2,3-dicarboximide

CBNumberCB9121858

SummenformelC9H9NO3

Molgewicht179.17

MOL-Datei21715-90-2.mol

Synonyma

N-Hydroxynorborn-5-en-2,3-dicarboximid

N-Hydroxynorborn-5-en-2,3-dicarboximid physikalisch-chemischer Eigenschaften

Schmelzpunkt	165-170 °C (lit.)
Siedepunkt	311.69°C (rough estimate)
Dichte	1.2822 (rough estimate)
Brechungsindex	1.5600 (estimate)
storage temp.	Sealed in dry,2-8°C
Löslichkeit	Soluble in ethanol
Aggregatzustand	Solid
pka	9.00±0.20(Predicted)
Farbe	Off-White
BRN	13540
CAS Datenbank	21715-90-2(CAS DataBase Reference)
EPA chemische Informationen	4,7-Methano-1H-isoindole-1,3(2H)-dione, 3a,4,7,7a-tetrahydro-2-hydroxy- (21715-90-2)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	26-36
WGK Germany	3
TSCA	Yes
HS Code	29280090

Gefahreninformationscode (GHS)

N-Hydroxy-5-norbornene-2,3-dicarboximide Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
N-Hydroxy-5-norbornene-2,3-dicarboximide (NHD) is a compound that has antiviral activity and is used to treat HIV infections. It inhibits the reverse transcriptase enzyme in the virus, which blocks the synthesis of viral DNA. The ferroelectric properties of NHD were first observed by observing changes in its melting point when mixed with water. This property makes it useful for diagnosis purposes. In animal studies, a dose of 5 mg/kg was found to be effective against cancer cells and the drug showed no toxicity in humans at doses up to 500 mg/day. The optimal reaction conditions for NHD are pH 6 and temperature 45 degrees Celsius.
Chemische Eigenschaften
white to off-white crystalline powder
Verwenden
It decreases racemization in peptide synthesis and inhibits formation of N-acylureas.
Verwenden
Inhibits racemization in peptide synthesis using DCC as condensing agent.
Verwenden
N-Hydroxy-5-norbornene-2,3-dicarboximide(HONB) is used in solution-phase peptide synthesis. Used in the synthesis of enkephalin analogs.
läuterung methode
Dissolve the imide in CHCl3, filter, evaporate and recrystallise from EtOAc. IR (nujol): max 1695, 1710 and 1770 (C=O), and 3100 (OH) cm-1. The O-acetyl derivative has m 113-114o (from EtOH) with IR bands at max 1730, 1770 and 1815 cm-1 only, and the O-benzoyl derivative has m 143-144o (from propan-2-ol or *C6H6). [Bauer & Miarka J Org Chem 24 1293 1959, Fujino et al. Chem Pharm Bull Jpn 22 1857 1974]. [Beilstein 21/10 V 188.]

N-Hydroxynorborn-5-en-2,3-dicarboximid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

21715-90-2, N-Hydroxy-5-norbornene-2,3-dicarboximide Verwandte Suche:

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