methoctramine tetrahydrochloride hemihydrate

methoctramine tetrahydrochloride hemihydrate Chemische Eigenschaften,Einsatz,Produktion Methoden

• Verwenden

  Methoctramine is a muscarinic M2 receptor antagonist.

• Verwenden

  Methoctramine hydrate has been used:
  
  • As a muscarinic receptor 2 antogonist.
  • As a test molecule to check its effect on premature osteogenic differentiation of HGPS (Hutchinson-Gilford progeria syndrome) iPS (induced pluripotent)-derived mesenchymal stem cells.

• Definition

  ChEBI: A hydrochloride obtained by combining methoctramine with four molar equivalents of hydrochloric acid.

• Allgemeine Beschreibung

  Methoctramine (N, N′-bis [6-[[(2-methoxyphenyl)-methyl] hexyl]-1, 8-octane] diamine) is a derivative of polymethylene tetramine.

• Biochem/physiol Actions

  Methoctramine is a selective M2 muscarinic receptor antagonist at nM concentrations. At mM concentrations, methoctramine directly inhibits the high affinity GTPase activity of G proteins. In oesophageal muscle, acetylcholine-mediated increase in calcium and arachidonic acid release were reduced by the M2 receptor antagonist, methoctramine. Methoctramine infused bilaterally in the dorsolateral striatum, considerably enhanced memory in cognitively impaired aged rats. Methoctramine plays a vital role in muscarinic receptor classification.

methoctramine tetrahydrochloride hemihydrate Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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