1,3-Dimethylbarbituric acid Struktur

1,3-Dimethylbarbitursure

Bezeichnung:1,3-Dimethylbarbitursure

CAS-Nr769-42-6

Englisch Name:1,3-Dimethylbarbituric acid

CBNumberCB9121414

SummenformelC6H8N2O3

Molgewicht156.14

MOL-Datei769-42-6.mol

Synonyma

1,3-Dimethylbarbitursure

1,3-Dimethylbarbitursure physikalisch-chemischer Eigenschaften

Schmelzpunkt	121-123 °C (lit.) 121-123 °C
Siedepunkt	228.1±23.0 °C(Predicted)
Dichte	1.322±0.06 g/cm3(Predicted)
storage temp.	-20°C Freezer
Löslichkeit	hot water: soluble0.5g/10 mL, clear, colorless to faintly yellow
Aggregatzustand	Crystalline Powder
pka	pK1:4.68(+1) (25°C)
Farbe	White/cream/pale yellow
Wasserlöslichkeit	Soluble in water.
BRN	139810
CAS Datenbank	769-42-6(CAS DataBase Reference)
NIST chemische Informationen	1,3-Dimethylbarbituric acid(769-42-6)
EPA chemische Informationen	2,4,6(1H,3H,5H)-Pyrimidinetrione, 1,3-dimethyl- (769-42-6)

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	22-41
S-Sätze:	26-36/39
WGK Germany	3
TSCA	Yes
HS Code	29339900

Gefahreninformationscode (GHS)

1,3-Dimethylbarbituric acid Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
R41:Gefahr ernster Augenschäden.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/39:Bei der Arbeit geeignete Schutzkleidung und Schutzbrille/Gesichtsschutz tragen.
Chemische Eigenschaften
Yellow or brownish powder
Verwenden
1,3-Dimethyl Barbituric Acid (Urapidil Impurity 4) is a derivative of Barbituric acid. All of the barbituric acid derivatives which have been reported to have pronounced hypnotic activity are disubstituted in the 5-position.
Verwenden
1,3-Dimethylbarbituric acid is used as a catalyst in the Knoevenagel condensation of a series of aromatic aldehydes. It is also used in the synthesis of 5-aryl-6-(alkyl- or aryl-amino)-1,3-dimethylfuro [2,3-d]pyrimidine derivatives and enantioselective synthesis of isochromene pyrimidinedione derivatives.
Allgemeine Beschreibung
1,3-Dimethylbarbituric acid (1,3-Dimethyl-2,4,6(1H,3H,5H)-pyrimidinetrione) is an active methylene compound. It undergoes hollow Pd₆ water-soluble cage, [{(tmen)Pd}₆(timb)₄](NO₃)₁₂ (tmen= N,N,N′,N′-tetramethylethylenediamine, timb=1,3,5-tris(1-imidazolyl)benzene)-catalyzed Knoevenagel condensation reaction with pyrene-1-carboxaldehyde. It undergoes self-sorted Pd₇ molecular boat having an internal nanocavity (catalyst)-assisted Knoevenagel condensation reaction with various aromatic aldehydes. It has been synthesized by reacting 1,3-dimethylurea, malonic acid and acetic anhydride in acetic acid. It is widely used for the synthesis of various synthetic intermediates and heterocyclic compounds.
läuterung methode
Crystallise the acid from water and sublime it in a vacuum. Also purify it by dissolving 10g in 100mL of boiling CCl4/CHCl3 (8:2) (1g charcoal), filtering and cooling to 25o. Dry it in vacuo [Kohn et al. Anal Chem 58 3184 1986]. [Beilstein 24 III/IV 1875.]

1,3-Dimethylbarbituric acid Upstream-Materialien And Downstream Produkte

1,3-Dimethylbarbitursure Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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