Scutellarin

Bezeichnung:Scutellarin

CAS-Nr27740-01-8

Englisch Name:Scutellarin

CBNumberCB9117918

SummenformelC21H18O12

Molgewicht462.36

MOL-Datei27740-01-8.mol

Scutellarin physikalisch-chemischer Eigenschaften

Schmelzpunkt	300～301℃
Siedepunkt	891.6±65.0 °C(Predicted)
Dichte	1.810±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,2-8°C
Löslichkeit	DMSO (Slightly), Methanol (Very Slightly, Sonicated)
pka	2.72±0.70(Predicted)
Farbe	Light Yellow to Yellow
BRN	71779
CAS Datenbank	27740-01-8(CAS DataBase Reference)

Sicherheit

S-Sätze:	24/25
WGK Germany	3
HS Code	29389090

Scutellarin Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
Scutellarin is a flavone that has been found in S. barbata and has diverse biological activities, including anticancer, lipid lowering, antioxidative, and neurocognitive properties. It inhibits proliferation of PC-9 and H1975 non-small cell lung cancer (NSCLC) cells in a concentration-dependent manner and induces apoptosis and autophagy when used at a concentration of 160 μM, effects that can be blocked by the autophagy inhibitor HCQ . Scutellarin (30 and 60 mg/kg per day) reduces tumor growth in an H1975 mouse xenograft model. It decreases serum total cholesterol and LDL-cholesterol and increases HDL-cholesterol in a high-fat diet-induced mouse model of non-alcoholic fatty liver disease (NAFLD) when administered at doses of 25 and 50 mg/kg. It decreases hepatic malondialdehyde (MDA), glutamic-oxalacetic transaminase (GOT), and glutamic-pyruvic transaminase (GPT) activity, increases catalase (CAT) and total antioxidative capacity (T-AOC) activity, and increases the hepatic expression of PPARγ, PGC-1α, and Nrf2 in the same model. Scutellarin (5, 25, and 50 mg/kg per day) also prevents deficits in spatial and novel object memory in rats in the Y maze and novel object recognition test, respectively.
Verwenden
Scutellarin is an active flavonoid component from the medical plant Erigeron breviscapus (Vant) Hand-Mazz. Scutellarin is used as a micrpcirculation promoter for the treatment of cardio-cerebrovascula r diseases. Studies suggest that Scutellarin has anti-cancer properties and has been shown to enhance apoptosis of tumor cells.
Verwenden
Scutellarin is an active flavonoid component from the medical plant Erigeron breviscapus (Vant) Hand-Mazz. Scutellarin is used as a micrpcirculation promoter for the treatment of cardio-cerebrovascular diseases. Studies suggest that Scutellarin has anti-cancer properties and has been shown to enhance apoptosis of tumor cells.
Definition
ChEBI: The glycosyloxyflavone which is the 7-O-glucuronide of scutellarein.

Scutellarin Upstream-Materialien And Downstream Produkte

Scutellarin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

27740-01-8, Scutellarin Verwandte Suche:

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