5-Hydroxy-L-tryptophan

Bezeichnung:5-Hydroxy-L-tryptophan

CAS-Nr4350-09-8

Englisch Name:L-5-Hydroxytryptophan

CBNumberCB9110025

SummenformelC11H12N2O3

Molgewicht220.22

MOL-Datei4350-09-8.mol

Synonyma

Oxitriptan

5-Hydroxy-L-tryptophan

5-Hydroxy-L-tryptophan physikalisch-chemischer Eigenschaften

Schmelzpunkt	270 °C (dec.) (lit.)
alpha	-32.5 º (c=1,H2O on dry basis)
Siedepunkt	361.16°C (rough estimate)
Dichte	0.902 g/mL at 25 °C (lit.)
Brechungsindex	n20/D 1.4850(lit.)
Flammpunkt	175 °F
storage temp.	2-8°C
Löslichkeit	H₂O: 10 mg/mL
Aggregatzustand	solid
pka	2.22±0.10(Predicted)
Farbe	white
Optische Aktivität	[α]22/D 30°, c = 1 in H2O
Wasserlöslichkeit	Slightly soluble
Merck	14,4847
BRN	88200
LogP	-0.140 (est)
CAS Datenbank	4350-09-8(CAS DataBase Reference)
EPA chemische Informationen	L-5-Hydroxytryptophan (4350-09-8)

Sicherheit

Kennzeichnung gefährlicher	Xn,Xi
R-Sätze:	22-36/37/38-65-20/21/22-20/21
S-Sätze:	36-26
RIDADR	UN 2811 6.1/PG 3
WGK Germany	3
RTECS-Nr.	YN7110000
F	3-10
TSCA	Yes
HazardClass	6.1
PackingGroup	III
HS Code	29339990

Gefahreninformationscode (GHS)

L-5-Hydroxytryptophan Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R65:Gesundheitsschädlich: kann beim Verschlucken Lungenschäden verursachen.
R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
R20/21:Gesundheitsschädlich beim Einatmen und bei Berührung mit der Haut.
S-Sätze Betriebsanweisung:
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Chemische Eigenschaften
white to pale grey powder
Verwenden
5-Hydroxy-L-Tryptophan is a hydroxylated metabolite of L-Tryptophan
Verwenden
A labelled metabolite of Tryptophan
Verwenden
5-Hydroxy-L-tryptophan has been used:
- to inject experimental mice for serotonin detection
- as a precursor of 5-hydroxytryptamine and injected in pregnant mice and neonatal rats for vital neutral red staining of lung slices
- as a standard in citrate-acetate buffer for its use in high performance liquid chromatography (HPLC) analysis
Definition
ChEBI: 5-hydroxy-L-tryptophan is the L-enantiomer of 5-hydroxytryptophan. It has a role as a human metabolite, a plant metabolite and a mouse metabolite. It is a 5-hydroxytryptophan, a hydroxy-L-tryptophan and a non-proteinogenic L-alpha-amino acid. It is an enantiomer of a 5-hydroxy-D-tryptophan. It is a tautomer of a 5-hydroxy-L-tryptophan zwitterion.
Allgemeine Beschreibung
Colorless to pale pink crystals.
Air & Water Reaktionen
L-5-Hydroxytryptophan is sensitive to air. Slightly water soluble .
Reaktivität anzeigen
L-5-Hydroxytryptophan reacts with bases. .
Brandgefahr
Flash point data for L-5-Hydroxytryptophan are not available, however, L-5-Hydroxytryptophan is probably combustible.
Handelsname
Levothym (Promonta Lundbeck, Germany), Lévotonine (Panpharma, France), Oxyfan (Coli, Italy), Tript-OH (Sigma- Tai, Italy).
Biochem/physiol Actions
Hydroxylation of L-tryptophan occurs in the brain during serotonin synthesis. This is a step that controls the production of serotonin and also yields 5-hydroxy-l-tryptophan (5-HTP) as a metabolite. Thus, consumption 5-HTP, increases the serotonin level, which might result in depression, lack of sleep and severe headache.
läuterung methode
Likely impurities are 5-hydroxy-D-tryptophan and 5-benzyloxytryptophan. Crystallise 5-hydroxy-L-tryptophan under nitrogen from water by adding EtOH. Store it under nitrogen. Also dissolve it in the minimum volume of hot H2O (~0.7g in 4mL) under nitrogen (charcoal) and allowed it to crystallise at 5o. The picrolonate crystallises from H2O with m 184-186o(dec). [Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 p 2732-2737 1961, Morris & Armstrong J Org Chem 22 306 1957, Beilstein 22/14 V 278.]

L-5-Hydroxytryptophan Upstream-Materialien And Downstream Produkte

5-Hydroxy-L-tryptophan Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

4350-09-8, L-5-Hydroxytryptophan Verwandte Suche:

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