Urea, N-(3-nitrophenyl)-N'-(4-phenyl-2-thiazolyl)-

Urea, N-(3-nitrophenyl)-N'-(4-phenyl-2-thiazolyl)- Chemische Eigenschaften,Einsatz,Produktion Methoden

• Biologische Aktivität

  BAZ1A-IN-1 is a potent inhibitor of BAZ1A (bromodomain-containing protein). BAZ1A-IN-1 shows a KD value of 0.52 μM against BAZ1A bromodomain. BAZ1A-IN-1 shows good anti-viability activity against cancer cell lines expressing a high level of BAZ1A, but weak or no activity against cancer cells with a low expression level of BAZ1A[1]. BAZ1A-IN-1 (Cpd-2) (0.015-100 μM; 96 hours) exhibits good anti-viability activity against all the four cancer cell lines that have a high expression level of BAZ1A, with IC50 values of 5.08 μM, 4.29 μM, 10.65 μM, and 7.70 μM for THP-1, ZR-75-30, BT474, and H1975 cells, respectively[1].

• Einzelnachweise

  [1]. Yang Z, et al. Discovery of BAZ1A bromodomain inhibitors with the aid of virtual screening and activity evaluation. Bioorg Med Chem Lett. 2021;33:127745.

Urea, N-(3-nitrophenyl)-N'-(4-phenyl-2-thiazolyl)- Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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