Pyrrolo[2,1-a]isoquinoline, 6-(4-ethynylphenyl)-1,2,3,5,6,10b-hexahydro-, trans- (9CI)

Pyrrolo[2,1-a]isoquinoline, 6-(4-ethynylphenyl)-1,2,3,5,6,10b-hexahydro-, trans- (9CI) Chemische Eigenschaften,Einsatz,Produktion Methoden

• Verwenden

  JNJ-7925476 is a triple reuptake inhibitor that selectively and potently inhibits the activity of the serotonin transporter (SERT), norepinephrine transporter (NET), and dopamine transporter (DAT). JNJ-7925476 is rapidly absorbed into the blood and its concentration in the brain is 7-fold higher than that in plasma. The occupancy ED(50) values of JNJ-7925476 for SERT, NET, and DAT in the rat brain are 0.18, 0.09, and 2.4 mg/kg, respectively. JNJ-7925476 rapidly induces a significant increase in the levels of extracellular serotonin, dopamine, and norepinephrine in the rat cerebral cortex in a dose-dependent manner. JNJ-7925476 exhibits potent antidepressant-like activity in the mouse tail suspension test. These results suggest that JNJ-7925476 has in vivo efficacy in biochemical and behavioral models of depression[1].

• Einzelnachweise

  [1] In-vitro and in-vivo characterization of JNJ-7925476, a novel triple monoamine uptake inhibitor DOI:10.1016/j.ejphar.2008.04.008

Pyrrolo[2,1-a]isoquinoline, 6-(4-ethynylphenyl)-1,2,3,5,6,10b-hexahydro-, trans- (9CI) Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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