Octanoic acid, 2-butyl-, 1,1'-[[(3-hydroxypropyl)imino]di-9,1-nonanediyl] ester

Octanoic acid, 2-butyl-, 1,1'-[[(3-hydroxypropyl)imino]di-9,1-nonanediyl] ester Chemische Eigenschaften,Einsatz,Produktion Methoden

• Beschreibung

  Lipid III-45 is an ionizable cationic lipid (pKa = 6.25).1 It has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA in vivo.1,2,3 LNPs containing lipid III-45 and encapsulating a luciferase mRNA reporter accumulate in liver and adipose tissue in mice.1,2 LNPs containing lipid III-45 have been used to deliver an mRNA sequence encoding an antibody targeting the tumor-associated antigen and tight junction integral protein claudin-18 isoform 2 (claudin-18.2) to mice and reduce tumor volume in an MDA-MB-231 mouse xenograft model.3WARNING This product is not for human or veterinary use.

• Einzelnachweise

  [1] De Souza, F.I., Zumiotti, A.V., and Da Silva, C.F. Neuregulins 1-α and 1-β on the regeneration the peripheral nerves[J]. Acta Ortop Bras.
  [2] ARCHER D F. Delivery of therapeutic agents to the target tissue.[J]. Menopause: The Journal of The North American Menopause Society, 2011, 18 10: 1040-1041. DOI: 10.1097/gme.0b013e31822ff238
  [3] De Souza, F.I., Zumiotti, A.V., and Da Silva, C.F. Neuregulins 1-α and 1-β on the regeneration the peripheral nerves[J]. Acta Ortop Bras.

Octanoic acid, 2-butyl-, 1,1'-[[(3-hydroxypropyl)imino]di-9,1-nonanediyl] ester Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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