Pilocarpidin

pilocarpidine Chemische Eigenschaften,Einsatz,Produktion Methoden

• Beschreibung

  The leaves of Pilocarpus Jaborandi contain this alkaloid but not those of P. microphyllus. The alkaloid is a viscous oil which decomposes on attempted distillation. It has [α]²⁰_D + 81.3° (H20) falling to + 35.2° on the addition of alkali. The salts are well crystallized and include the hydrochloride which has [α]~O + 72° (H20); nitrate, m.p. 137°C; [α]²⁰_D + 73.2° (H20); aurichloride, m.p. 125 C and the platinichloride tetrahydrate, m.p. 187°C (dry, dec.). In contrast to the corresponding salts of pilocarpine and isopilocarpine (q.v.) the picrate is a non-crystallizable oil. When heated with alkalies, the salts evolve dimethylamine and on treatment with alcoholic sodium methoxide, the base gives isopilocarpidine, characterized as the nitrate, m.p. 109-111 °C. The latter, on quaternary methylation furnishes isopilocarpine metho-salts, e.g. the methopicrate, m.p. 119-120°C.

• Definition

  ChEBI: Pilocarpidine is a gamma-lactone.

• Einzelnachweise

  Harnack., Annalen, 238,230 (1887)
  Jowett., J. Chem. Soc., 77,474 (1900)
  Burtles, Pyman, Roylance., ibid, 127,581 (1925)
  Spath, Kunz., Ber., 58,513 (1925)
  Preobrashenski et al., ibid, 69, 1837 (1936)
  

Pilocarpidin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global(2)Suppliers