Fenspirid

Bezeichnung:Fenspirid

CAS-Nr5053-06-5

Englisch Name:fenspiride

CBNumberCB8875352

SummenformelC15H20N2O2

Molgewicht260.33

MOL-Datei5053-06-5.mol

Synonyma

Fenspirid

Fenspirid physikalisch-chemischer Eigenschaften

Siedepunkt	126-127 °C(Press: 2 Torr)
Dichte	1.19±0.1 g/cm3(Predicted)
pka	12.44±0.20(Predicted)
Aggregatzustand	Solid:particulate/powder
LogP	1.798-1.802 at 20℃ and pH6

Gefahreninformationscode (GHS)

fenspiride Chemische Eigenschaften,Einsatz,Produktion Methoden

Originator
Viarespan,Servier,France,1969
Verwenden
Bronchodilator;anti-adrenergic (β-receptor).
Definition
ChEBI: 8-(2-phenylethyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one is an azaspiro compound.
Manufacturing Process
A solution of 192 g of 1-phenethyl-4-hydroxy-4-aminomethyl piperidine in 800 cc of diethylcarbonate is heated for 2? hours to reflux at about 80°C in the presence of sodium methylate (prepared for immediate use from 2 g of sodium). After this time, the ethyl alcohol formed during the reaction is slowly distilled while the maximum temperature is reached. The excess ethyl carbonate is distilled under reduced pressure. A crystallized residue is then obtained, which is stirred with 400 cc of water and 400 cc of ether. The solution is filtered and 125 g (77.6%) of practically pure product melting at 232°C to 233°C, are obtained.
The starting material was prepared in a yield of 58% by reduction of the corresponding cyanohydrin. It in turn was prepared from 1-(2-phenylethyl)-4- piperidone and potassium cyanide to give the cyanohydrin which was reduced by lithium aluminum hydride.
Therapeutic Function
Bronchodilator
Pharmazeutische Anwendungen
Fenspiride is an antagonist of 5-hydroxytryptamine, whose effect on bronchial smooth muscle expansion is between isoproterenol and theophylline. It also has the effect of unobtrusion-free respiratory tract and air resistance elimination in the lungs. It has the effect of antitussive, antipyretic, analgesic and anti-inflammatory, and the antipyretic and analgesic effect is better than aminopyrine and the anti-inflammatory effect is stronger than bute.

fenspiride Upstream-Materialien And Downstream Produkte

Fenspirid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

5053-06-5, fenspiride Verwandte Suche:

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