Diethylnitrosamin

Bezeichnung:Diethylnitrosamin

CAS-Nr55-18-5

Englisch Name:N-NITROSODIETHYLAMINE

CBNumberCB8732709

SummenformelC4H10N2O

Molgewicht102.14

MOL-Datei55-18-5.mol

Synonyma

Diethylnitrosoamin

Diethylnitrosamin

Diethylnitrosamin physikalisch-chemischer Eigenschaften

Schmelzpunkt	<25℃
Siedepunkt	177 °C (lit.)
Dichte	0.95 g/mL (lit.)
Dampfdruck	1.7 mmHg at 20 °C
Brechungsindex	n20/D 1.437
storage temp.	2-8°C
Löslichkeit	Chloroform (Soluble), Ethyl Acetate (Slightly), Methanol (Slightly)
Aggregatzustand	liquid
pka	-3.14±0.70(Predicted)
Farbe	yellow
Wasserlöslichkeit	106.2g/L(24 ºC)
Merck	6636
BRN	1744991
Stabilität	Stable, but light sensitive. Combustible. Incompatible with strong oxidizing agents, reducing agents.
CAS Datenbank	55-18-5(CAS DataBase Reference)
IARC	2A (Vol. 17, Sup 7) 1987
EPA chemische Informationen	N-Nitrosodiethylamine (55-18-5)

Sicherheit

Kennzeichnung gefährlicher	T,F
R-Sätze:	45-22-39/23/24/25-23/24/25-11
S-Sätze:	53-45-36/37-16
RIDADR	UN 2810 6.1/PG 3
WGK Germany	3
RTECS-Nr.	IA3500000
HazardClass	6.1(b)
PackingGroup	III
HS Code	29299090
Giftige Stoffe Daten	55-18-5(Hazardous Substances Data)
Toxizität	LD50 oral (rat) 280 mg/kg

Gefahreninformationscode (GHS)

N-NITROSODIETHYLAMINE Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R45:Kann Krebs erzeugen.
R22:Gesundheitsschädlich beim Verschlucken.
R39/23/24/25:Giftig: ernste Gefahr irreversiblen Schadens durch Einatmen, Berührung mit der Haut und durch Verschlucken.
R23/24/25:Giftig beim Einatmen, Verschlucken und Berührung mit der Haut.
R11:Leichtentzündlich.
S-Sätze Betriebsanweisung:
S53:Exposition vermeiden - vor Gebrauch besondere Anweisungen einholen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S16:Von Zündquellen fernhalten - Nicht rauchen.
Chemische Eigenschaften
N-Nitrosodiethylamine is a yellow liquid.
Verwenden
Gasoline and lubricant additive; antioxidant; stabilizer in plastics.
Verwenden
N-Nitrosodiethylamine (DEN) is a widely occurring nitrosamine that is one of the most important environmental carcinogens primarily inducing tumors of liver.
Verwenden
N,N-diethylnitrous Amide is a useful research reagent for organic synthesis.
Definition
ChEBI: A nitrosamine that is N-ethylethanamine substituted by a nitroso group at the N-atom.
Allgemeine Beschreibung
Clear slightly yellow liquid. Boiling point 175-177°C. Can reasonably be anticipated to be a carcinogen. Used as a gasoline and lubricant additive and as an antioxidant and stabilizer in plastics.
Air & Water Reaktionen
Water soluble.
Reaktivität anzeigen
N-NITROSODIETHYLAMINE reacts with strong oxidizing agents. Incompatible with reducing agents. Can be hydrolyzed by hydrogen bromide in acetic acid .
Hazard
Possible carcinogen; mutagen; neoplastigen; tumorigen; poison; teratogen.
Health Hazard
The acute toxicity of diethylnitrosamine is classified as moderate. Other nitrosamines of higher molecular weight are somewhat less toxic. Harmful exposure to nitrosamines can occur by inhalation and ingestion and may cause nausea, vomiting, and fever. This substance does not have adequate warning properties. Chronic exposure to nitrosamines can cause severe liver damage. Diethylnitrosamine is listed in IARC Group 2A ("probable human carcinogen") and is classified as an OSHA "select carcinogen." Nitrosamines are suspected of causing cancers of the lung, nasal sinuses, brain, esophagus, stomach, liver, bladder, and kidney. Diethylnitrosamine is mutagenic and teratogenic.
Health Hazard
ACUTE/CHRONIC HAZARDS: When heated to decomposition N-NITROSODIETHYLAMINE emits toxic fumes of nitrogen oxides.
Brandgefahr
Volatilization during combustion produces hazardous vapors. Combustion products contain nitrogen oxides.
Brandgefahr
N-NITROSODIETHYLAMINE is combustible.
Flammability and Explosibility
Volatilization during combustion produces hazardous vapors. Combustion products contain nitrogen oxides.
Biochem/physiol Actions
N-Nitrosodiethylamine (NDMA) is carcinogenic in all animal species tested. The main target organs are the nasal cavity, trachea, lung, esophagus and liver. NDMA is acted upon by the cytochrome P450 system resulting in the formation of carcinogenic methyldiazonium ion. However microbes like Pseudomonas metabolize NDMA into N-nitromethylamine (NTMA) and formaldehyde.
Sicherheitsprofil
Confirmed carcinogen with experimental carcinogenic, neoplastigenic, and tumorigenic data. Poison by ingestion, intravenous, intraperitoneal, and subcutaneous routes. An experimental teratogen. Other experimental reproductive effects. Human mutation data reported. A transplacental carcinogen. When heated to decomposition it emits toxic fumes of NOx. See also N-NITROSO COMPOUNDS and AMINES.
mögliche Exposition
An additive in gasoline and lubricants; an antioxidant and stabilizer in plastics. Used in research. Incompatibilities: Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. Contact with reducing agents may form hydrazine; hydrogen bromide. Light sensitive; rapidly decomposes.
Carcinogenicity
N-Nitrosodiethylamine is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.
Lager
work with diethylnitrosamine should be conducted in a fume hood to prevent exposure by inhalation, and appropriate impermeable gloves and splash goggles should be worn at all times to prevent skin and eye contact.
Versand/Shipping
UN2810 Toxic liquids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required. UN3082 Environmentally hazardous substances, liquid, n.o.s., Hazard Class: 9; Labels: 9-Miscellaneous hazardous material, Technical Name Required.
Inkompatibilitäten
An additive in gasoline and lubricants; an antioxidant and stabilizer in plastics. Used in research. Incompatibilities: Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. Contact with reducing agents may form hydrazine; hydrogen bromide. Light sensitive; rapidly decomposes.
Waste disposal
Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal. Under 40 CFR 261.5 small quantity generators of this waste may qualify for partial exclusion from hazardous waste regulations.

N-NITROSODIETHYLAMINE Upstream-Materialien And Downstream Produkte

Diethylnitrosamin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

55-18-5, N-NITROSODIETHYLAMINE Verwandte Suche:

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