Calcifediol Monohydrate

Bezeichnung:Calcifediol Monohydrate

CAS-Nr63283-36-3

Englisch Name:Calcifediol Monohydrate

CBNumberCB8727251

SummenformelC27H46O3

Molgewicht418.66

MOL-Datei63283-36-3.mol

Calcifediol Monohydrate physikalisch-chemischer Eigenschaften

Flammpunkt	14℃
storage temp.	-20°C
Löslichkeit	Practically insoluble in water, freely soluble in ethanol (96 per cent), soluble in fatty oils.
Farbe	White to Light yellow
BRN	4270041
InChIKey	JWUBBDSIWDLEOM-LCDSLSDMSA-N
SMILES	C[C@]12CCC/C(=C\C=C3\C[C@@H](O)CCC\3=C)/[C@]1([H])CC[C@]2([H])[C@H](C)CCCC(O)(C)C.O \|&1:1,10,16,20,22,r\|
CAS Datenbank	63283-36-3(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	T+
R-Sätze:	28-48/25-26-24/25
S-Sätze:	28-36/37-45
RIDADR	UN 2811 6.1/PG 2
WGK Germany	3
F	8-10-19
HS Code	29362900

Gefahreninformationscode (GHS)

Calcifediol Monohydrate Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R28:Sehr giftig beim Verschlucken.
S-Sätze Betriebsanweisung:
S28:Bei Berührung mit der Haut sofort abwaschen mit viel . . . (vom Hersteller anzugeben).
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
Chemische Eigenschaften
White or almost white crystals.
Verwenden
Calcifediol is a major circulating metabolite of vitamin D3 and acts as a competitive inhibitor with an apparent Ki of 3.9 μM. It is produced in the liver and is the best indicator of the body’s vitamin D stores. It is effective in the treatment of ricket
Verwenden
25-Hydroxyvitamin D3 may be used as a certified reference material (CRM) for the determination of the analyte in biological samples by chromatography techniques.
Definition
ChEBI: Calcifediol monohydrate is a vitamin D.
Trademarks
Calderol (Organon).
Allgemeine Beschreibung
A Certified Spiking Solution^? of 25-Hydroxyvitamin D3, a prohormone whose blood serum levels are used to determine Vitamin D nutritional status. This solution standard is suitable for critical quantitative applications in research and clinical environments including: for use in preparation of controls and calibrators for LC/UV and LC-MS/MS assays; as system tuning/suitability standards; linearity verification; internal proficiency testing; and for OEM use in preparation of reagents, development of assays and instrument IQ/OQ. The stable, quantitative solution format provides significant benefits to the user including material savings, increased efficiency of labor, and convenience of use. The shelf stable Snap-N-Spike^? format allows laboratories to eliminate painstaking weighing operations and provides the ability to spike a known concentration of analyte into their matrix of choice just before use.
Biochem/physiol Actions
Cholecalciferol is an inactive form of vitamin D3 which undergoes various levels of hydroxylation to form active vitamin D3 analogs. 1α-Hydroxyvitamin D3 (alfacalcidol) is a synthetic analog that is metabolized to 1,25-dihydroxycholecalciferol, the biologically active form of vitamin D3. Other analogues of cholecalciferol result from different hydroxylations. 25-dihydroxycholecalciferol is a the major circulating form of vitamin D3 and a physiological precursor of 1α,25-Dihydroxycholecalciferol. The conversion is catalyzed by 25-Hydroxyvitamin D3 1-α-hydroxylase (VD3 1A hydroxylase) also known ascytochrome p450 27B1 (CYP27B1).
target
IL Receptor
Dosage
Calcidiol monohydrate contains the monohydrate form of the major circulating metabolite of vitamin D3 in the body and is a source of 1,25-dihydroxyvitamin D, the biologically active form of vitamin D. Calciferol monohydrate (25-hydroxycholecalciferol monohydrate) is safe under recommended conditions and level of use (up to 10 μg/day) and is safe for children >11 years of age and adults, including pregnant and lactating women.

Calcifediol Monohydrate Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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