Mangiferin

Bezeichnung:Mangiferin

CAS-Nr4773-96-0

Englisch Name:Mangiferin

CBNumberCB8723435

SummenformelC19H18O11

Molgewicht422.34

MOL-Datei4773-96-0.mol

Mangiferin physikalisch-chemischer Eigenschaften

Schmelzpunkt	269-270°C
storage temp.	2-8°C
Löslichkeit	DMSO (Slightly, Sonicated), Methanol (Slightly), Pyridine (Slightly, Heated)
Siedepunkt	842.7±65.0 °C(Predicted)
Dichte	1.843±0.06 g/cm3(Predicted)
pka	6.09±0.20(Predicted)
Aggregatzustand	Solid
Farbe	Pale Yellow
Stabilität	Hygroscopic
InChIKey	AEDDIBAIWPIIBD-AZBPZEDSNA-N
SMILES	OC1=C([C@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)C(O)=CC2OC3=CC(O)=C(O)C=C3C(=O)C1=2 \|&1:3,4,5,7,9,r\|
LogP	0.130 (est)
CAS Datenbank	4773-96-0(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	T+,Xi,Xn
R-Sätze:	28-36/37/38-22
S-Sätze:	22-28-36/37-45-36-26-24/25
RIDADR	UN 3462 6.1/PG 1
WGK Germany	3
RTECS-Nr.	OP1927800
HS Code	29389090

Gefahreninformationscode (GHS)

Mangiferin Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R28:Sehr giftig beim Verschlucken.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S28:Bei Berührung mit der Haut sofort abwaschen mit viel . . . (vom Hersteller anzugeben).
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Beschreibung
Mangiferin is a plant natural polyphenol of C-glycosylxanthone structure and various pharmacological activities. It can be found in many plant species, among which the mango tree (Mangifera indica) is one of the primary sources. Mangiferin is also present in some medicinal herbs, influencing their therapeutic and preventive properties, and in honeybush (Cyclopia sp.), a popular South African herbal tea. Mangiferin dissolves well in water, so it can be easily extracted into infusions and decoctions. In the mangiferin molecule, four aromatic hydroxyl groups determine its strong antiradical and antioxidant properties. Mangiferin is also an efficient iron chelator, therefore preventing the generation of hydroxyl radicals in Fenton-type reactions[1].
Chemische Eigenschaften
Yellow powder
Verwenden
MAO inhibitor, immunostimulant
Verwenden
Mangiferin is a xanthonoid, a chemical compound found in mangoes and in Anemarrhena asphodeloides rhizomes. Mangiferin has effect of hepatinica and choleretic, and is used to therapy hepatitis. Mangiferin is an anti-inflammatory, antivirotic, central nervous system inhibit function and immunologic suppression. Mangiferin has curative effect on chronic bronchitis. Mangiferin has cytotoxicity effect on hepatocellularcarcinoma ce1l, and may induce apoptosis. Mangiferin has the effect of antioxidation and delaying caducity.
Definition
ChEBI: A C-glycosyl compound consisting of 1,3,6,7-tetrahydroxyxanthen-9-one having a beta-D-glucosyl residue at the 6-position.
Allgemeine Beschreibung
Mangiferin (MGF) is a natural bioactive polyphenol predominantly isolated from the Mangifera indica (Mango) tree. It has a xanthone glucoside structure. Mangiferin can also be found in other angiosperm plants and herbs.
Biochem/physiol Actions
Mangiferin has various pharmacological properties including antioxidant, anti-diabetic, anti-bacterial, cardioprotective, neuroprotective, and immunomodulatory activities. It has also displayed antidiabetic, antihyperlipidemic, and antiatherogenic properties in streptozotocin-induced diabetic rats. MGF exerts chemotherapeutic and chemo-preventative activities. It displays antioxidant, analgesic, and hepatoprotective activity against carbon tetrachloride-induced liver injury. MGF is a known accelerator of gastrointestinal transit (GIT).
Einzelnachweise
[1] Adam Matkowski. “Mangiferin - a bioactive xanthonoid, not only from mango and not just antioxidant.” Mini reviews in medicinal chemistry 13 3 (2013): 439–55.

Mangiferin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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