6-((4-Nitrobenzyl)thio)-9-β-D-ribofuranosylpurin

S-(4-NITROBENZYL)-6-THIOINOSINE Chemische Eigenschaften,Einsatz,Produktion Methoden

• S-Sätze Betriebsanweisung:

  S24/25:Berührung mit den Augen und der Haut vermeiden.

• Chemische Eigenschaften

  Off-White Solid

• Verwenden

  It is a prototype inhibitor of the human equilibrative nucleoside transporter (hENT1), and is a high affinity ligand with a Kd of 0.1-1.0 nM. Nucleoside transporter inhibitors have potential therapeutic applications as anticancer, antiviral, cardio

• Verwenden

  S-(4-Nitrobenzyl)-6-thioinosine is a nucleoside analog and an inhibitor of the human equilibrative nucleoside transporter (hENT1) (1,2,3). Nucleoside transporter inhibitors are useful compounds to investigate anticancer, antiviral, cardioprotective, and neuroprotective agents.

• Definition

  ChEBI: NBMPR is a purine nucleoside.

• Allgemeine Beschreibung

  S-(4-Nitrobenzyl)-6-thioinosine (NBTI) belongs to the family of S⁶-substituted 6-thiopurine nucleosides, which regulate nucleoside transport mechanisms in animals. It acts as a ligand of adenosine transporter. Binding sites for NBTI is located on brain capillaries. It functions as a covalent photoaffinity probe for nucleoside transport.

• Biologische Aktivität

  Equilibrative nucleoside transporter 1 (ENT1) inhibitor (K i values are 0.4 and 2800 nM for hENT1 and hENT2 respectively).

• Biochem/physiol Actions

  Inhibitor of equilibrative nucleoside transporters (ENTs), particularly adenosine transporters, in central nervous system and vascular smooth muscle.

• Lager

  Store at +4°C

S-(4-NITROBENZYL)-6-THIOINOSINE Upstream-Materialien And Downstream Produkte

6-((4-Nitrobenzyl)thio)-9-β-D-ribofuranosylpurin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global(99)Suppliers

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