SIBUTRAMINE HYDROCHLORIDE MONOHYDRATE

Bezeichnung:SIBUTRAMINE HYDROCHLORIDE MONOHYDRATE

Englisch Name:SIBUTRAMINE HYDROCHLORIDE MONOHYDRATE

CBNumberCB8708494

SummenformelC17H29Cl2NO

Molgewicht334.32

SIBUTRAMINE HYDROCHLORIDE MONOHYDRATE physikalisch-chemischer Eigenschaften

Sicherheit

Kennzeichnung gefährlicher	Xi,T,F
R-Sätze:	36/37/38-39/23/24/25-23/24/25-11
S-Sätze:	22-24/25-36-26-45-36/37-16-7
RIDADR	UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany	3

Gefahreninformationscode (GHS)

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Beschreibung
Sibutramine was introduced as Meridia in the US for the control of obesity, in conjunction with a reduced-calorie diet. Sibutramine can be prepared in four steps from 4-chlorobenzyl cyanide. Sibutramine acts as a serotonin and noradrenaline reuptake inhibitor ; in animal studies, it reduces energy intake by creating a satieted feeling and increases energy expenditure by enhancing thermogenesis. In a clinical study in obese patients treated with 10 or 15 mg of Sibutramine once-daily, meaningful weight loss was sustained for 12 months ; an additional study demonstrated a lack of abuse potential. An appreciable part of Sibutramine's effect would also be due to its 2N-mono and didesmethylmetabolites, which are very potent monoamine reuptake inhibitors themselves.
Chemische Eigenschaften
White Solid
Originator
Knoll (Germany)
Verwenden
A serotonin and noradrenaline reuptake inhibitor (SNR). Decreases calorie intake and increases energy expenditure
Verwenden
antihyperlipidemic
Verwenden
antiobesity agent;neurotransmitter reuptake inhibitor
Trademarks
Meridia (Abbott);Meridia, Reductil.