Imipenem

Bezeichnung:Imipenem

CAS-Nr74431-23-5

Englisch Name:Imipenem

CBNumberCB8695769

SummenformelC12H19N3O5S

Molgewicht317.36

MOL-Datei74431-23-5.mol

Imipenem physikalisch-chemischer Eigenschaften

Schmelzpunkt	193-198°C
Siedepunkt	567℃
RTECS-Nr.	CL5446516
Flammpunkt	>110°(230°F)
storage temp.	Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
Löslichkeit	H2O: >5mg/mL
pka	pKa 3.2/9.9(H2O,t = 25) (Uncertain)
Aggregatzustand	powder
Farbe	white to beige
Wasserlöslichkeit	Soluble in water at 5mg/ml
CAS Datenbank	74431-23-5(CAS DataBase Reference)

Sicherheit

WGK Germany	3
HS Code	2941906000

Gefahreninformationscode (GHS)

Imipenem Chemische Eigenschaften,Einsatz,Produktion Methoden

Chemische Eigenschaften
Off-White Solid
Verwenden
antidiabetic
Verwenden
antiulcer
Verwenden
An extremely broad-spectrum semi-synthetic antibiotic
Verwenden
Imipenem has a broad spectrum of antimicrobial action, which includes most clinically significant microorganisms: Gram-positive, Gram-negative, aerobic, and anaerobic. It is resistant with respect to most beta-lactamases of Gram-positive and Gram-negative bacteria. It is used for bacterial infections of the lower respiratory tract, infections of the urinary and sexual tracts, infections of bones, joints, skin, soft tissues, intraabdominal and gynecological infections, bacterial septicemia, and endocarditis.
Imipenem undergoes enzymatic inactivation in the kidneys. In order to avoid this problem, it is used in a 1:1 ratio in combination with cilastatin—the sodium salt of [R-[R,S-(Z)]]-7-[(2- amino-2-carboxyethyl)thio]-2-[[(2,2-dimethylcyclopropyl)aminocarbonyl-2-heptenoic acid (32.1.3.6), which inhibits metabolisms of imipenem in the kidneys. This combination of two compounds is also used in medicine under the name primaxin.
Definition
ChEBI: Imipenem hydrate is a member of carbapenems. It contains an imipenem.
Allgemeine Beschreibung
Chemical structure: ?-lactam
Biochem/physiol Actions
Imipenem is found effective against gram positive and negative aerobes and anaerobes. Imipenem is often combined with cilastatin, to inhibit its metabolism in kidney.
Synthese
Imipenem, [5R-[5|á,6|á(R)]]-6-(1-hydroxyethyl)-3-[[2-[(iminomethyl)amino] ethyl]thio]-7-oxo-1-azabicyclo[3.2.0]hept-2-en-2-carboxylic acid (32.1.3.1), is the only carbapenem presently used in clinics. It is synthesized from thienamycin isolated from Streptomyces cattleya by reacting it with the methyl formimidate.

Unlike penicillins and cephalosporins, which have a side aminoacyl group joined to the betalactam ring, imipenem has a |á-hydroxyethyl side chain. Significant resistance to hydrolysis by beta-lactamases is observed in this compound, evidently thanks to the trans-configuration of the side chain, while the side chain of penicillins and cephalosporins have a cis configuration.

Imipenem Upstream-Materialien And Downstream Produkte

Imipenem Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

74431-23-5, Imipenem Verwandte Suche:

Send Inquriy