2-Imino-1-methylimidazolidin-4-on

Bezeichnung:2-Imino-1-methylimidazolidin-4-on

CAS-Nr60-27-5

Englisch Name:Creatinine

CBNumberCB8672212

SummenformelC4H7N3O

Molgewicht113.12

MOL-Datei60-27-5.mol

Synonyma

2-Imino-1-methylimidazolidin-4-on

2-Imino-1-methylimidazolidin-4-on physikalisch-chemischer Eigenschaften

Schmelzpunkt	295 °C (dec.) (lit.)
Siedepunkt	211.83°C (rough estimate)
Dichte	1.2526 (rough estimate)
Brechungsindex	1.5700 (estimate)
Flammpunkt	290 °C
storage temp.	Sealed in dry,Room Temperature
Löslichkeit	1 M HCl: 0.1 g/mL at 20 °C, clear
pka	4.83(at 25℃)
Aggregatzustand	Crystalline Powder
Farbe	White
Säure-Base-Indikators(pH-Indikatoren)	7.5 - 8.5
Wasserlöslichkeit	SOLUBLE
Merck	14,2569
BRN	112061
Stabilität	Stable. Incompatible with strong oxidizing agents.
InChIKey	DDRJAANPRJIHGJ-UHFFFAOYSA-N
LogP	-1.760
CAS Datenbank	60-27-5(CAS DataBase Reference)
NIST chemische Informationen	Creatinine(60-27-5)
EPA chemische Informationen	4H-Imidazol-4-one, 2-amino-1,5-dihydro-1-methyl- (60-27-5)

Sicherheit

Kennzeichnung gefährlicher	Xi,Xn
R-Sätze:	34-36/37/38-20/21/22
S-Sätze:	26-36/37/39-45-24/25-36
RIDADR	UN 1789 8/PG 3
WGK Germany	3
F	9-23
TSCA	Yes
HS Code	29332990
Toxizität	A degradation product of creatine. Serum creatinine is elevated after eating meat. High serum creatinine may also be indicative of renal failure.

Gefahreninformationscode (GHS)

Creatinine Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R34:Verursacht Verätzungen.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S24/25:Berührung mit den Augen und der Haut vermeiden.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
Creatinine is together with urea, the most widely known "uremic toxin", and is usually assessed when- ever a reduction in kidney function is suspected. This is mainly because creatinine evaluation is cheap, widely accessible and relatively well reflects the renal function. It also forms the basis for estimation of estimated glomerular filtration rate (eGFR) and thus is a major component of all principal eGFR equations.
Creatinine, which is nonenzymatically produced from the creatine pool in skeletal muscle, but is also to some extent generated from exogenous creatine present in meat, is the major guanidine compound retained in patients with diminished glomerular filtration rate. Creatinine is routinely determined in plasma or serum as a measure of impairment of renal function and it might be expected that a variety of uremic symptoms correlate with the plasma creatinine level; this does not, however, necessarily imply a causal relationship. In fact, high serum creatinine levels correlate with low mortality in HD patients, presumably because the creatinine generation rate reflects the size of the muscle mass. Creatinine seems to be relatively nontoxic. Large amounts of creatinine have been fed to healthy subjects without any adverse effects and animals also tolerate large doses.
Chemische Eigenschaften
white powder
Verwenden
metabolic enhancer
Verwenden
Creatinine levels in blood and urine may be used to calculate the creatinine clearance (CrCl), which reflects the glomerular filtration rate (GFR), an important clinical index of renal function. It is a substrate for creatininase.
Verwenden
Creatinine is the end product of creatine catabolism. Creatinine is a normal constituent of urine. Also found together with creatine in muscle tissues and blood. Creatinine is found in all soils and i n grain seeds and other vegetable matter as well as in certain fish and in crab meat extract.
Definition
ChEBI: A lactam obtained by formal cyclocondensation of creatine. It is a metabolite of creatine.
Biologische Funktion
Creatinine is a byproduct of a chemical compound called creatine, which helps muscles get the energy that they need. As a waste product, creatinine is filtered out of the blood by the kidneys and removed from the body in urine.
A creatinine test measures the amount of this chemical in either the blood or urine. Creatinine levels can provide an indication of how well the kidneys are working.
Creatinine may be measured alone or included in a panel of tests that include other compounds found in the urine or blood.
https://labtestsonline.org/tests/creatinine
https://www.kidney.org/atoz/content/what-creatinine
Allgemeine Beschreibung
Creatinine is a breakdown product formed by the degradation of creatine phosphate from muscles. The kidneys extract creatinine from the body by filtering almost all of it from the blood and excreting it in the urine. Serum creatinine is the most commonly used indicator for renal functioning. In chemical synthesis, creatinine is used as a heterocyclic nitrogenous compound that produces electron-rich and highly basic creatinine derivatives.
läuterung methode
Likely impurities are creatine and ammonium chloride. Dissolve it in dilute HCl, then neutralise with ammonia. Recrystallise it from H2O by adding excess of Me2CO. The picrate crystallises from 23volumes of boiling H2O and has m 220-221o(dec). [King J Chem Soc 2377 1930, Beilstein 25 III/IV 2543.]

Creatinine Upstream-Materialien And Downstream Produkte

2-Imino-1-methylimidazolidin-4-on Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

60-27-5, Creatinine Verwandte Suche:

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