Climbazol

Bezeichnung:Climbazol

Englisch Name:Climbazole

CBNumberCB8671477

SummenformelC15H17ClN2O2

Molgewicht292.76

Synonyma

Climbazol

Climbazol physikalisch-chemischer Eigenschaften

Schmelzpunkt	96-100°C
Siedepunkt	447.5±40.0 °C(Predicted)
Dichte	1.17±0.1 g/cm3(Predicted)
Dampfdruck	0.001Pa at 25℃
Brechungsindex	1.54
storage temp.	Inert atmosphere,Room Temperature
Löslichkeit	Insoluble in water
pka	5.66±0.22(Predicted)
Farbe	White to Almost white
Wasserlöslichkeit	58mg/L at 25℃
BRN	618020
InChIKey	OWEGWHBOCFMBLP-UHFFFAOYSA-N
LogP	3.83 at 25℃
CAS Datenbank	38083-17-9(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xn,N
R-Sätze:	22-50/53
S-Sätze:	60-61
RIDADR	UN 3077
WGK Germany	3
RTECS-Nr.	EL7085000
HS Code	29332900

Gefahreninformationscode (GHS)

R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
Beschreibung
(±)-Climbazole is an imidazole antifungal agent. It inhibits the growth of C. albicans (MIC = 0.29 μg/ml), as well as clinical isolates of M. pachydermatis (MICs = <0.06-1 μg/ml) and M. furfur (MICs = <0.06-0.5 μg/ml) in vitro. It also reduces the size of Malassezia populations on the skin of naturally infected dogs when used at a dose of 2% in shampoo. (±)-Climbazole (80 mg/kg) increases the levels of cytochrome P450 in rat liver. Formulations containing climbazole have been used in the treatment of dandruff.
Chemische Eigenschaften
White Solid
Verwenden
Climbazole is an imidazole antifungal agent that can provide anti-dandruff benefits when incorporated into a shampoo matrix. s assay and did not induce micronuclei in human lymphocytes.
Definition
ChEBI: 1-(4-chlorophenoxy)-1-(1H-imidazol-1-yl)-3,3-dimethylbutan-2-one is a ketone that is butan-2-one substituted by a 4-chlorophenoxy and a 1H-imidazol-1-yl group at position 1 and 2 methyl groups at position 3. It is a member of monochlorobenzenes, a member of imidazoles, an aromatic ether, a ketone and a hemiaminal ether.
Hazard
Moderately toxic by ingestion. Low toxicity by skin contact.
Flammability and Explosibility
Non flammable
Nebenwirkungen
May cause localized irritation of the skin with symptoms including redness, rashes and itching.