2'-Deoxy-2'-fluorocytidine

Bezeichnung:2'-Deoxy-2'-fluorocytidine

CAS-Nr10212-20-1

Englisch Name:2'-Deoxy-2'-fluorocytidine

CBNumberCB8670324

SummenformelC9H12FN3O4

Molgewicht245.21

MOL-Datei10212-20-1.mol

2'-Deoxy-2'-fluorocytidine physikalisch-chemischer Eigenschaften

Schmelzpunkt	167 °C
Siedepunkt	500.1±60.0 °C(Predicted)
Dichte	1.82±0.1 g/cm3(Predicted)
Brechungsindex	80 ° (C=1, MeOH)
storage temp.	Keep in dark place,Sealed in dry,2-8°C
Löslichkeit	Soluble in DMSO, Methanol.
pka	12.84±0.70(Predicted)
Aggregatzustand	Powder
Farbe	White to Off-white
Wasserlöslichkeit	Water: 5 mg/mL (20.39 mM; ultrasonic and warming and heat to 60°C)
InChI	InChI=1S/C9H12FN3O4/c10-6-7(15)4(3-14)17-8(6)13-2-1-5(11)12-9(13)16/h1-2,4,6-8,14-15H,3H2,(H2,11,12,16)/t4-,6-,7-,8-/m1/s1
InChIKey	NVZFZMCNALTPBY-XVFCMESISA-N
SMILES	OC[C@H]1O[C@@H](N2C=CC(N)=NC2=O)[C@H](F)[C@@H]1O
CAS Datenbank	10212-20-1(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	26-36
HS Code	29389090

Gefahreninformationscode (GHS)

2'-Deoxy-2'-fluorocytidine Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
2'-Deoxy-2'-fluorocytidine is a nucleoside analog. It has antiviral effects and can synergize with T705 to effectively inhibit Crimean-Congo hemorrhagic fever virus (CCHFV) replication. 2'-Deoxy-2'-fluorocytidine can also inhibit dihydrofolate reductase, thereby preventing the production of tetrahydrofolate, which is required for the synthesis of purines and pyrimidines. It has a certain inhibitory effect on poliovirus, herpes simplex virus, vesicular stomatitis virus and influenza A virus.
Chemische Eigenschaften
White Solid
Verwenden
2'-Deoxy-2'-fluorocytidine is a potent inhibitor of the subgenomic hepatitis C virus replicon in Huh-7 cells. 2'-Deoxy-2'-fluorocytidine has been shown to inhibit Borna Disease virus replication and s pread.
in vitro
2'-Deoxy-2'-fluorocytidine has antiviral activities, showing 50% effective concentrations (EC50) of 61 nM and 31 nM against CCHFV and CCHFV/ZsG in Huh7 cells, respectively. And it shows a 50% cytotoxicity concentration (CC50) of >50.0 μM in Huh7 cells.
Einzelnachweise
[1] Stephen R. Welch. “Identification of 2′-deoxy-2′-fluorocytidine as a potent inhibitor of Crimean-Congo hemorrhagic fever virus replication using a recombinant fluorescent reporter virus.” Antiviral research 147 (2017): Pages 91-99.

2'-Deoxy-2'-fluorocytidine Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

10212-20-1, 2'-Deoxy-2'-fluorocytidine Verwandte Suche:

Send Inquriy