DMNQ Struktur

DMNQ

Bezeichnung:DMNQ

CAS-Nr6956-96-3

Englisch Name:DMNQ

CBNumberCB8667087

SummenformelC12H10O4

Molgewicht218.21

MOL-Datei6956-96-3.mol

DMNQ physikalisch-chemischer Eigenschaften

storage temp.	-20°C
Löslichkeit	Soluble in DMSO (up to 10 mg/ml) or in Ethanol (up to 5 mg/ml).
Aggregatzustand	solid
Farbe	Yellow
Stabilität	Stable for 1 year as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	26-36
WGK Germany	3

Gefahreninformationscode (GHS)

DMNQ Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
DMNQ is a 1,4-naphthoquinone that acts as a redox-cycling agent, typically increasing intracellular superoxide and hydrogen peroxide formation. The amount of oxidative stress is proportional to the amount of DMNQ applied and can alter diverse cellular parameters, including signal transduction, mitochondrial function, and gene expression.
Verwenden
DMNQ is a non-alkylating redox cycling quinone.
Verwenden
2,3-Dimethoxy-1,4-naphthoquinone has been used to investigate the effects of ethanol on podocyte apoptosis under hypoxic and hyperoxic conditions.
Definition
ChEBI: A naphthoquinone that is 1,4-naphthoquinone bearing two methoxy substituents at positions 2 and 3. Redox-cycling agent that induces intracellular superoxide anion formation and, depending on the concentration, induces cell proliferation, apoptosis or necro is. Used to study the role of ROS in cell toxicity, apoptosis, and necrosis.
Biochem/physiol Actions
2,3-dimethoxy-1,4-naphthoquinone (DMNQ) has the ability to produce H2O2?through redox cycling but fails to conjugate with glutathione (GSH).
Lager
+4°C
Einzelnachweise
References/Citations 1) Gant?et al. (1988)?Redox Cycling and Sulphydryl Arylation; Their Relative Importance in the Mechanism of Quinone Cytotoxicity to Isolated Hepatocytes; Chem. Biol. Interactions;?65?157 2) Stubberfield and Cohen (1989)?Interconversion of NAD(H) to NADP(H). A cellular response to quinone-induced oxidative stress in isolated hepatocytes; Biochem. Pharmacol.,?38?2631 3) Dypbukt?et al?(1994)?Different prooxidant levels stimulate growth, trigger apoptosis or produce necreosis of insulin-secreting RINm5F cells. The role of intracellular polyamines; J. Biol. Chem.,?269?30553 4) Henry and Wallace (1996)?Differential mechanisms of cell killing by redox cycling and arylating quinones; Arch. Toxicol.,?70?482

DMNQ Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

6956-96-3, DMNQ Verwandte Suche:

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