Rabacfosadine succinate

Rabacfosadine succinate Chemische Eigenschaften,Einsatz,Produktion Methoden

• Beschreibung

  Rabacfosadine succinate, also known as VDC-1101 or GS-9219, is a double prodrug of the nucleotide analogue 9-(2-phosphonylmethoxyethl)guanine (PMEG). It is a novel chemotherapy drug approved for the treatment of lymphoma in dogs. Rabacfosadine administered every 3 weeks is usually well tolerated and has shown significant anti-tumour activity in dogs with previously untreated medium and large cell lymphoma.

• Verwenden

  Rabacfosadine succinate is used as the acyclic nucleoside phosphonate PMEG double prodrug.

• Mechanism of action

  Rabacfosadine succinate targets lymphocytes and acts as an anti-tumour agent by inhibiting DNA synthesis through the inhibition of DNA polymerase.

• Nebenwirkungen

  The most common adverse reaction to Rabacfosadine succinate is gastrointestinal (anorexia/diarrhoea), which is generally resolved by supportive therapy and/or dose adjustment. Three dogs developed VCOG-CTCAE grade 5 delayed pulmonary fibrosis.

Rabacfosadine succinate Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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