α-Tocopherylhydrogensuccinat

Bezeichnung:α-Tocopherylhydrogensuccinat

CAS-Nr4345-03-3

Englisch Name:D-α-Tocopherol succinate

CBNumberCB8483476

SummenformelC33H54O5

Molgewicht530.78

MOL-Datei4345-03-3.mol

Synonyma

α-Tocopherylhydrogensuccinat

α-Tocopherylhydrogensuccinat physikalisch-chemischer Eigenschaften

Schmelzpunkt	~76 °C(lit.)
Siedepunkt	625.8±55.0 °C(Predicted)
Dichte	1.002±0.06 g/cm3(Predicted)
Dampfdruck	0Pa at 20℃
storage temp.	-20°C
Löslichkeit	Practically insoluble in water, very soluble in methylene chloride, soluble in acetone and in anhydrous ethanol.
pka	4.35±0.17(Predicted)
Farbe	White or off-white
Geruch (Odor)	Little or no odor
maximale Wellenlänge (λmax)	286nm(EtOH)(lit.)
Merck	14,9495
BRN	4038233
Stabilität	Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
LogP	12 at 25℃
CAS Datenbank	4345-03-3(CAS DataBase Reference)
EPA chemische Informationen	D-.alpha.-Tocopheryl acid succinate (4345-03-3)

Sicherheit

WGK Germany	1
RTECS-Nr.	EJ9984000
F	8-10-23
HS Code	2936280000
Toxizität	LD50 oral in rat: > 7gm/kg

Gefahreninformationscode (GHS)

D-α-Tocopherol succinate Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
Tocopherol succinate (4345-03-3) is a potent antioxidant. Protects mice from gamma-radiation by induction of granulocyte-colony stimulating factor.1,2?Tocopherol succinate induces apoptosis in human gastric cancer cells3?and inhibits proliferation of mesothelioma cells by down-regulation of fibroblast growth factor receptor-14. Induces apoptosis in neuroblastoma cells.5
Chemische Eigenschaften
Off-White to Pale Yellow Solid
Verwenden
A potent novel antineoplastic agent with high selectivity and cooperativity with tumor necrosis factor-related apoptosis-inducing ligand (Apo2 ligand). It inhibits proliferation of mesothelioma cells by selective down-regulation of fibroblast growth factor receptors. Furthermore, it has been shown to enhance the anti-tumor effect of dendritic cell vaccines.
Verwenden
A potent novel antineoplastic agent with high selectivity and cooperativity with tumor necrosis factor-related apoptosis-inducing ligand (Apo2 ligand). It inhibits proliferation of mesothelioma cells by selective down-regulation of fibroblast growth factor receptors. Furthermore, it has been shown to enhance the anti-tumor effect of dendritic cell vaccines.
Verwenden
A potent antioxidant tocopherol
Definition
ChEBI: Tocopherol succinate is a tocol and a hemisuccinate.
Allgemeine Beschreibung
White powder.
Air & Water Reaktionen
Insoluble in water.
Reaktivität anzeigen
Vitamin E succinate is an ester. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides.
Brandgefahr
Flash point data for Vitamin E succinate are not available; however, Vitamin E succinate is probably combustible.
Flammability and Explosibility
Not classified
Biochem/physiol Actions
Tocopherol exhibits antioxidant property by protecting the cells and membranes from oxidative stress. In plants, high levels of α-tocopherol leads to plant stress tolerance whereas low levels is associated with oxidative stress. In humans, tocopherol prevents cancer, premature aging, atherosclerosis, arthritis caused due to free radicals. Vitamin E succinate (VES) is an anti-tumor analog of vitamin E.
Sicherheitsprofil
When heated to decomposition it emits acrid smoke and irritating fumes.
Einzelnachweise
1) Singh?et al. (2010),?Alpha-tocopherol succinate protects mice from gamma-radiation by induction of granulocyte-colony stimulating factor; Int. J. Radiation Biol.,?86?12 2) Singh?et al. (2009),?Tocopherol succinate: a promising radiation countermeasure; Immunopharmacol.,?9?1423 3) Wu?et al. (2004),?c-Jun N-terminal kinase is required for vitamin E succinate-induced apoptosis in human gastric cancer cells; J. Gastroenterol.,?10?1110 4) Stapelberg?et al. (2004),?alpha-Tocopheryl succinate inhibits proliferation of mesothelioma cells by selective down-regulation of fibroblast growth factor receptors; Biochem. Biophys. Res. Commun.,?318?636 5) Swettenham?et al. (2005),?Alpha-tocopheryl succinate selectively induces apoptosis in neuroblastoma cells: potential therapy of malignancies of the nervous system; J. Neurochem.,?94?1448

α-Tocopherylhydrogensuccinat Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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