HMTase Inhibitor IV, UNC0638 - Calbiochem

HMTase Inhibitor IV, UNC0638 - Calbiochem Chemische Eigenschaften,Einsatz,Produktion Methoden

• Allgemeine Beschreibung

  A cell-permeable quinazolinamine compound that acts as a potent and reversible inhibitor of G9a and GLP HMTases (histone methyltransferases) (IC₅₀ = ≤ 15 and 19 nM for G9a and GLP, respectively) and displays ~15-fold greater selectivity over DNMT1 and minimally blocks the activities of JMJD2E (IC₅₀ = 4.66 μM) and SETD7, SETD8, PRMT3 and SUV39H2 (IC₅₀ >10 μM). Shown to lower H3K9Me2 levels in MDA-MB231 cells (IC₅₀ = 81 nM; EC₅₀ = 11.2 μM for cell toxicity) and 6-fold more potent than the HMTase Inhibitor, BIX-01294, (Cat. No. 382190). Also, affects the activities of adrenergic α_1A, adrenergic α_1B and muscarinic _M2 by 90%, 69% and 64% and a panel of 26-receptors and ion-channels by ≤ 30% at 1 μM.
  
  
  
  
  This probe is supplied in conjunction with the Structural Genomics Consortium (SGC). For further characterization details, please visit the UNC0638 probe summary on the SGC website.

HMTase Inhibitor IV, UNC0638 - Calbiochem Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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