N-Benzyliden-tert-butylamin-N-ether

Bezeichnung:N-Benzyliden-tert-butylamin-N-ether

CAS-Nr3376-24-7

Englisch Name:N-TERT-BUTYL-ALPHA-PHENYLNITRONE

CBNumberCB8469861

SummenformelC11H15NO

Molgewicht177.24

MOL-Datei3376-24-7.mol

Synonyma

N-Benzyliden-tert-butylamin-N-ether

N-Benzyliden-tert-butylamin-N-ether physikalisch-chemischer Eigenschaften

Schmelzpunkt	73-74 °C(lit.)
Siedepunkt	283℃
Dichte	0.990
Brechungsindex	1.5480 (estimate)
Flammpunkt	119℃
storage temp.	Store at <= 20°C.
Löslichkeit	DMSO: soluble
Aggregatzustand	powder
pka	1.50±0.53(Predicted)
Farbe	white
Wasserlöslichkeit	Soluble in DMSO (10 mg/ml), chloroform (50 mg/ml), and water (20 mg/ml).
Merck	14,7056
BRN	2044028
CAS Datenbank	3376-24-7(CAS DataBase Reference)
EPA chemische Informationen	2-Propanamine, 2-methyl-N-(phenylmethylene)-, N-oxide (3376-24-7)

Sicherheit

S-Sätze:	22-24/25
WGK Germany	3
RTECS-Nr.	TX1760000
F	10
TSCA	Yes
HS Code	2929 90 00

Gefahreninformationscode (GHS)

N-TERT-BUTYL-ALPHA-PHENYLNITRONE Chemische Eigenschaften,Einsatz,Produktion Methoden

S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
Chemische Eigenschaften
white to light beige fine crystalline powder
Verwenden
N-tert-Butyl-α-phenylnitrone has been used:
- as a component of Dneasy Blood&Tissue buffer to preserve the oxidized state of DNA extracted from human non-tumorigenic epithelial breast (MCF10A) cells
- as a free radical scavenger of reactive oxygen species (ROS) in microglial (MG) cell lines
- to attenuate fibroblast senescence in unstable oral squamous cell carcinomas (GU-OSCC)
Verwenden
Spin trap reagent for carbon- or oxygen- or nitrogen-centered free radicals.
Verwenden
N-tert-Butyl-a-phenylnitrone is a commonly-used free radical trap. It contains radical scavenging activity and an ability to inhibit Cox-2 (cyclooxygenase-2). N-tert-Butyl-a-phenylnitrone is an antioxidant that has been shown to act as a protective agent in several experimental models of neurodegenerative disorders. N-tert-Butyl-a-phenylnitrone inhibits lipid peroxidation in rat liver microsomes. It also prevents the induction of inducible nitric oxide synthase (iNOS) by reactive oxygen species.
Synthesis Reference(s)
Tetrahedron, 48, p. 8677, 1992 DOI: 10.1016/S0040-4020(01)89443-6
Allgemeine Beschreibung
Most commonly-used free radical trap. An antioxidant that has been shown to act as a protective agent in several experimental models of neurodegenerative disorders. Inhibits lipid peroxidation in rat liver microsomes. Also prevents the induction of inducible nitric oxide synthase (iNOS) by reactive oxygen species.
Biochem/physiol Actions
Product does not compete with ATP.
läuterung methode
Crystallise PBN from hexane. It is a free radical trap. [cf Janzen Methods Enzymology 105 188 1984, Beilstein 7 IV 519.]

N-TERT-BUTYL-ALPHA-PHENYLNITRONE Upstream-Materialien And Downstream Produkte

N-Benzyliden-tert-butylamin-N-ether Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

3376-24-7, N-TERT-BUTYL-ALPHA-PHENYLNITRONE Verwandte Suche:

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