(S)-3,5-DIHYDROXYPHENYLGLYCINE Struktur

(S)-3,5-DIHYDROXYPHENYLGLYCINE

Bezeichnung:(S)-3,5-DIHYDROXYPHENYLGLYCINE

CAS-Nr162870-29-3

Englisch Name:(S)-3,5-DIHYDROXYPHENYLGLYCINE

CBNumberCB8453891

SummenformelC8H9NO4

Molgewicht183.16

MOL-Datei162870-29-3.mol

(S)-3,5-DIHYDROXYPHENYLGLYCINE physikalisch-chemischer Eigenschaften

Schmelzpunkt	>207°C (dec.)
Siedepunkt	448.8±33.0 °C(Predicted)
Dichte	1.550±0.06 g/cm3(Predicted)
storage temp.	−20°C
Löslichkeit	Aqueous Base (Very Slightly, Sonicated), Methanol (Slightly), Water (Slightly, Heated)
pka	1.77±0.10(Predicted)
Aggregatzustand	solid
Farbe	white
Wasserlöslichkeit	Soluble to 50 mM in water
Stabilität	Hygroscopic

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	26-36
WGK Germany	3

Gefahreninformationscode (GHS)

(S)-3,5-DIHYDROXYPHENYLGLYCINE Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Verwenden
(S)-3,5-Dihydroxylphenylglycine is a potent agonist of group I metabotropic glutamate receptors mGluR1 and mGluR5. (S)-3,5-Dihydroxylphenylglycine have been utilized for the treatment of neuronal inju ry and cognitive enhancement.
Verwenden
(S)-3,5-Dihydroxylphenylglycine is a potent agonist of group I metabotropic glutamate receptors mGluR1 and mGluR5. (S)-3,5-Dihydroxylphenylglycine have been utilized for the treatment of neuronal injury and cognitive enhancement.
Verwenden
(S)-3,5-Dihydroxyphenylglycine hydrate has been used:
- as mGluR1/5?agonist for metabotropic glutamate receptor 1 (mGluR1/5) activation in synaptoneurosomal preparations
- in ACSF for DHPG stimulation
- to inject into basolateral amygdala to study its effect on memory expression
Definition
ChEBI: (S)-3,5-dihydroxyphenylglycine is a glycine derivative that is L-alpha-phenylglycine substituted at positions 3 and 5 on the phenyl ring by hydroxy groups. It is a member of resorcinols and a non-proteinogenic L-alpha-amino acid. It is functionally related to a L-alpha-phenylglycine. It is a tautomer of a (S)-3,5-dihydroxyphenylglycine zwitterion.
Biologische Aktivität
Selective group I mGlu receptor agonist. Also available as part of the Group I mGlu Receptor Tocriset™ and Mixed mGlu Receptor Tocriset™ .
Biochem/physiol Actions
(S)-3,5-Dihydroxyphenylglycine hydrate is a group I metabotropic glutamate receptor agonist.
Lager
-20°C (desiccate). Protect from light.

(S)-3,5-DIHYDROXYPHENYLGLYCINE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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