3,5-DIHYDROXY-4'-BROMOSTILBENE

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Warnung

• Gefahrenhinweise

  H315：Verursacht Hautreizungen.

  H319：Verursacht schwere Augenreizung.

  H335：Kann die Atemwege reizen.

• Sicherheit

  P261：Einatmen von Staub vermeiden.

  P264：Nach Gebrauch gründlich waschen.

  P264：Nach Gebrauch gründlich waschen.

  P271：Nur im Freien oder in gut belüfteten Räumen verwenden.

  P280：Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.

  P302+P352：BEI BERÜHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckmäßig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen.

  P305+P351+P338：BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

3,5-DIHYDROXY-4'-BROMOSTILBENE Chemische Eigenschaften,Einsatz,Produktion Methoden

• Biologische Aktivität

  4'-bromo-resveratrol is a sirt1 and sirt3 inhibitor.sirtuins are protein deacetylases regulating aging processes and many physiological functions. resveratrol activates human sirt1 and inhibits sirt3, and can mimic calorie restriction effects including lifespan extension in lower organisms.

• in vitro

  sirtuin modulation was studied by using 4’-bromo-resveratrol in a previous study. 4’-bromo-resveratrol inhibited sirt3 with much higher potency than resveratrol, and it also inhibited rather than activated sirt1. crystal structures of human sirt3/peptide complexes of 4’ -bromo-resveratrol identified two binding sites. an internal site caused the potent inhibitory effect. 4’-bromo-resveratrol interfered with nad+ and substrate peptide binding, and it extended its bromo-phenyl group in a unrecognized site pocket. the second binding site for 4’-bromo-resveratrol was found to be located on the surface of sirt3 and connected via two helices to peptide-binding active site loops. in sirt1, this site appeared to comprise a residue that was essential for its activation by small molecules and 4’-bromo-resveratrol therefore constituted a candidate for the long-sought allosteric sirt1 activator binding site [1].

• Einzelnachweise

  [1] nguyen gt, gertz m, steegborn c. crystal structures of sirt3 complexes with 4'-bromo-resveratrol reveal binding sites and inhibition mechanism. chem biol. 2013 nov 21;20(11):1375-85.

3,5-DIHYDROXY-4'-BROMOSTILBENE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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