KN-62

Bezeichnung:KN-62

CAS-Nr127191-97-3

Englisch Name:KN-62

CBNumberCB8443368

SummenformelC38H35N5O6S2

Molgewicht721.84

MOL-Datei127191-97-3.mol

KN-62 physikalisch-chemischer Eigenschaften

Schmelzpunkt	92-94°C
Siedepunkt	964.7±75.0 °C(Predicted)
Dichte	1.388
storage temp.	-20°C
Löslichkeit	45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.93 mg/mL
Aggregatzustand	solid
pka	4.07±0.13(Predicted)
Farbe	white
CAS Datenbank	127191-97-3(CAS DataBase Reference)

Sicherheit

S-Sätze:	24/25
WGK Germany	3
HS Code	29339980

KN-62 Chemische Eigenschaften,Einsatz,Produktion Methoden

S-Sätze Betriebsanweisung:
S24/25:Berührung mit den Augen und der Haut vermeiden.
Chemische Eigenschaften
Yellow Solid
Verwenden
It is used as a potent and selective inhibitor of CaMKII. KN-62 has demonstrated potent and selective inhibition of Ca2+/calmodulin-dependent protein kinase II (CaMKII; Ki=0.9 ?M) which causes cells to arrest in the S phase. In HEK-293 cells expressing type III adenylyl cyclase (III-AC), 10 ?M of KN-62 blocked CaMKII phosphorylation of III-AC, and inhibited hormone-stimulated Ca2+ oscillations. Additionally, KN-62 is a potent non-competitive antagonist at the P2X7 receptor (IC50 = 15 nM).
Verwenden
selectively inhibits rat brain Ca2+/cadmodulin-dependent protein kinase II,
Verwenden
A specific inhibitor of Ca2+/Calmodulin-dependent protein kinase II
Definition
ChEBI: 5-isoquinolinesulfonic acid [4-[(2S)-2-[5-isoquinolinylsulfonyl(methyl)amino]-3-oxo-3-(4-phenyl-1-piperazinyl)propyl]phenyl] ester is a member of piperazines.
Allgemeine Beschreibung
A cell-permeable, reversible, and selective inhibitor of CaM kinase II (K_i = 900 nM for rat brain CaM kinase II) that binds directly to the calmodulin binding site of the enzyme. Also inhibits the growth of K562 cells in a dose-dependent manner.
Biologische Aktivität
Selective, cell-permeable inhibitor of CaM kinase II (IC 50 = 0.9 μ M). Binds directly to the calmodulin binding site of the enzyme. Potent non-competitive antagonist at the P2X 7 receptor (IC 50 = 15 nM). Also available as part of the Mixed Kinase Inhibitor Tocriset™ .
Biochem/physiol Actions
Selectively inhibits rat brain Ca2+/calmodulin-dependent protein kinase II.
Lager
-20°C (desiccate)

KN-62 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

127191-97-3, KN-62 Verwandte Suche:

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