2-[4-(4-Chlorbenzoyl)phenoxy]-2-methylpropionsure

Bezeichnung:2-[4-(4-Chlorbenzoyl)phenoxy]-2-methylpropionsure

CAS-Nr42017-89-0

Englisch Name:Fenofibric acid

CBNumberCB8400259

SummenformelC17H15ClO4

Molgewicht318.75

MOL-Datei42017-89-0.mol

Synonyma

2-[4-(4-Chlorbenzoyl)phenoxy]-2-methylpropionsure

2-[4-(4-Chlorbenzoyl)phenoxy]-2-methylpropionsure physikalisch-chemischer Eigenschaften

Schmelzpunkt	177-179°C
Siedepunkt	486.5±35.0 °C(Predicted)
Dichte	1.286±0.06 g/cm3(Predicted)
storage temp.	2-8°C
Löslichkeit	Chloroform (Slightly), Methanol (Slightly)
pka	3.09±0.10(Predicted)
Aggregatzustand	powder
Farbe	White to Off-White
BRN	2058973
InChI	InChI=1S/C17H15ClO4/c1-17(2,16(20)21)22-14-9-5-12(6-10-14)15(19)11-3-7-13(18)8-4-11/h3-10H,1-2H3,(H,20,21)
InChIKey	MQOBSOSZFYZQOK-UHFFFAOYSA-N
SMILES	C(O)(=O)C(OC1=CC=C(C(=O)C2=CC=C(Cl)C=C2)C=C1)(C)C
CAS Datenbank	42017-89-0(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xn,N
R-Sätze:	36/37/38-50/53-22
S-Sätze:	26-36/37/39-61-60-24/25
RIDADR	UN 3077 9 / PGIII
WGK Germany	3
RTECS-Nr.	UA2453000
HazardClass	9
PackingGroup	III
HS Code	29189900
Toxizität	LD50 oral in rat: 1242mg/kg

Gefahreninformationscode (GHS)

Fenofibric acid Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
Chemische Eigenschaften
Fenofibric acid is a white to almost white crystalline powder that is stable under ordinary conditions and has a melting point of 179 – 183°C. Its empirical formula is C17H15ClO4 and molecular weight 318.75. Fenofibric acid is insoluble in water; its solubility increases with pH in buffered media.
Verwenden
DPP4 inhibitor, antidiabetic
Verwenden
Fenofibric acid, the active metabolite of fenofibrate. Increases Apolipoprotein A-I–Mediated High-Density Lipoprotein Biogenesis by enhancing transcription of ATP-Binding cassette transporter A1 gene in a liver X receptor–dependent manner.
Verwenden
Fenofibric acid, the active metabolite of fenofibrate. Increases Apolipoprotein A-Iediated High-Density Lipoprotein Biogenesis by enhancing transcription of ATP-Binding cassette transporter A1 gene in a liver X receptorependent manner
Definition
ChEBI: A monocarboxylic acid that is 2-methylpropanoic acid substituted by a 4-(4-chlorobenzoyl)phenoxy group at position 2. It is a metabolite of the drug fenofibrate.
Stoffwechsel
Fenofibric acid is primarily conjugated with glucuronic acid and then excreted in urine. A small amount of fenofibric acid is reduced at the carbonyl moiety to a benzhydrol metabolite, which is, in turn, conjugated with glucuronic acid and excreted in urine. In vitro and in vivo metabolism data indicate that fenofibric acid does not undergo oxidative metabolism (e.g. cytochrome P450) to a significant extent. The enzymes CYP1A2, CYP2A6, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6, CYP2E1, and CYP3A4 do not play a role in the metabolism of fenofibric acid.

Fenofibric acid Upstream-Materialien And Downstream Produkte

2-[4-(4-Chlorbenzoyl)phenoxy]-2-methylpropionsure Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

42017-89-0, Fenofibric acid Verwandte Suche:

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