6-Hydroxy-2-naphthoic acid

Bezeichnung:6-Hydroxy-2-naphthoic acid

Englisch Name:6-Hydroxy-2-naphthoic acid

CBNumberCB8398824

SummenformelC11H8O3

Molgewicht188.18

6-Hydroxy-2-naphthoic acid physikalisch-chemischer Eigenschaften

Schmelzpunkt	240-250 °C (lit.)
Siedepunkt	283.17°C (rough estimate)
Dichte	1.2100 (rough estimate)
Dampfdruck	0Pa at 25℃
Brechungsindex	1.6400 (estimate)
storage temp.	Sealed in dry,Room Temperature
Löslichkeit	Insoluble in water
Aggregatzustand	Powder
pka	4.34±0.30(Predicted)
Farbe	Pale brown
Wasserlöslichkeit	99mg/L at 20℃
BRN	2692084
LogP	2.1
CAS Datenbank	16712-64-4(CAS DataBase Reference)
EPA chemische Informationen	6-Hydroxy-2-naphthoic acid (16712-64-4)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	37/39-26-24/25
WGK Germany	3
RTECS-Nr.	QN3722500
TSCA	Yes
HS Code	29181990
Toxizität	rat,LD50,oral,3080mg/kg (3080mg/kg),PERIPHERAL NERVE AND SENSATION: SENSORY CHANGE INVOLVING PERIPHERAL NERVEGASTROINTESTINAL: OTHER CHANGESLUNGS, THORAX, OR RESPIRATION: OTHER CHANGES,National Technical Information Service. Vol. OTS0534748,

Gefahreninformationscode (GHS)

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Chemische Eigenschaften
pale brown powder
Verwenden
6-Hydroxy-2-naphthoic acid may be used in the synthesis of 5-bromo-6-hydroxy-2-naphthoic acid and liquid-crystalline epoxy resins.
Verwenden
6-hydroxy-2-naphthoic acid is used for preparation engineering plastics, organic pigments, liquid crystal materials, medicine, particularly as a monomer of heat-resistant material.
Definition
ChEBI: 6-Hydroxy-2-naphthoic acid is a naphthoic acid.
Allgemeine Beschreibung
6-Hydroxy-2-naphthoic acid is a hydroxynaphthoic acid derivative. Whole cells of the recombinant Escherichia coli strain expressing CYP199A2 were reported to catalyze the regioselective oxidation of 6-hydroxy-2-naphthoic acid to afford 6,7-dihydroxynaphthoic acid. It can form co-crystals with caffeine.
Flammability and Explosibility
Non flammable
Synthese
6-Hydroxy-2-naphthoic acid [16712-64-4], mp 245 – 248℃, is synthesized by carboxylation of the potassium salt of 2-naphthol at 170 – 230℃. It couples with diazo compounds in the 5-position and undergoes sulfonation in the 4- and 7-positions.