Clorsulon

Bezeichnung:Clorsulon

CAS-Nr60200-06-8

Englisch Name:Clorsulon

CBNumberCB8375438

SummenformelC8H8Cl3N3O4S2

Molgewicht380.66

MOL-Datei60200-06-8.mol

Synonyma

Clorsulon

Clorsulon physikalisch-chemischer Eigenschaften

Schmelzpunkt	194-203°C
Siedepunkt	651.7±65.0 °C(Predicted)
Dichte	1.800±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Inert atmosphere,2-8°C
Löslichkeit	DMSO (Slightly), Methanol (Slightly)
pka	9.16±0.60(Predicted)
Farbe	White
CAS Datenbank	60200-06-8(CAS DataBase Reference)

Sicherheit

S-Sätze:	24/25
WGK Germany	2
RTECS-Nr.	CZ9090000
HS Code	29350090
Toxizität	LD50 in mice (mg/kg): 761 i.p.; >10,000 orally (Ostlind)

Gefahreninformationscode (GHS)

Clorsulon Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
Clorsulon is a sulfonamide antiparasitic agent. It induces swelling and blebbing and reduces motility of F. hepatica mature flukes when used at a concentration of 10 μg/ml. In vivo, clorsulon (3.5-15 mg/kg) reduces the number of flukes in a goat model of F. hepatica infection. It completely eradicates naturally acquired F. hepatica adult flukes in sheep and cattle when administered at a dose of 7 mg/kg. Formulations containing clorsulon have been used in the treatment of liver flukes in sheep and cattle.
Chemische Eigenschaften
Crystalline Solid
Verwenden
A benzenedisulfonamide derivative with fasciolicidal activity. Anthelmintic (Trematodes).
Verwenden
analgesic, antiinflammatory
Definition
ChEBI: 4-amino-6-(1,2,2-trichloroethenyl)benzene-1,3-disulfonamide is a sulfonamide and a member of benzenes.
Trademarks
Curatrem [Veterinary] (Merial).
Veterinary Drugs and Treatments
Clorsulon is approved for use in the treatment of immature and adult forms of Fasciola hepatica (Liver fluke) in cattle. It is not effective against immature flukes less than 8 weeks old. It also has activity against Fasciola gigantica. Although not approved, the drug has been used in practice in various other species (e.g., sheep, llamas). It has activity against F. magna in sheep, but is not completely effective in eradicating the organism after a single dose, thus severely limiting its clinical usefulness against this parasite. Clorsulon is also not effective against the rumen fluke (Paramphistomum).

Clorsulon Upstream-Materialien And Downstream Produkte

Clorsulon Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

60200-06-8, Clorsulon Verwandte Suche:

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