DFMO

DFMO Chemische Eigenschaften,Einsatz,Produktion Methoden

• Chemische Eigenschaften

  Off-white powder

• Verwenden

  DL-α-Difluoromethylornithine hydrochloride hydrate has been used to reduce the effects of arginine on cell proliferation. It has also been used to investigate the effect of bisphenol A (BPA) on the migration of an established ovine trophectoderm (oTr1) cell line.

• Definition

  ChEBI: Eflornithine is a fluoroamino acid that is ornithine substituted by a difluoromethyl group at position 2. It has a role as a trypanocidal drug. It is a fluoroamino acid and an alpha-amino acid. It is functionally related to an ornithine.

• Allgemeine Beschreibung

  Difluoromethylornithine is a?fluorinated ornithine analog, which acts as a rate-limiting enzyme of polyamine biosynthesis. It is used to treat female facial hirsutism and human African trypanosomiasis. Difluoromethylornithine functions as a chemopreventive and chemotherapeutic agent against neuroblastoma and colorectal cancer. It exhibits cytostatic?effects on mammalian cells and tissues.

• Biologische Aktivität

  Inhibitor of ornithine decarboxylase that inhibits polyamine biosynthesis. Displays antiapoptotic, antiangiogenic and antiparasitic activity.

• Biochem/physiol Actions

  Difluoromethylornithine (Eflornithine) inhibits polyamine biosynthesis by the selective, irreversible inhibition of ornithine decarboxylase (ODC). A chemoprotective agent that blocks angiogenesis.

DFMO Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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