Gonadotropin, chorionisch

Bezeichnung:Gonadotropin, chorionisch

CAS-Nr9002-61-3

Englisch Name:Chorionic Gonadotropin

CBNumberCB8353322

SummenformelC17H28

Molgewicht232.40422

MOL-Datei9002-61-3.mol

Synonyma

Gonadotropin, chorionisch

Gonadotropin, chorionisch physikalisch-chemischer Eigenschaften

storage temp.	2-8°C
Löslichkeit	H2O: soluble1ML/vial
Aggregatzustand	lyophilized powder

Sicherheit

Kennzeichnung gefährlicher	B,Xn
R-Sätze:	63-62
S-Sätze:	22-36-36/37
WGK Germany	3
RTECS-Nr.	MD6953000
HS Code	2937190000
Giftige Stoffe Daten	9002-61-3(Hazardous Substances Data)

Gefahreninformationscode (GHS)

Chorionic Gonadotropin Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R63:Kann das Kind im Mutterleib möglicherweise schädigen.
S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
White or yellowish-white, amorphous powder.
Verwenden
Gonad-stimulating principle.
Verwenden
Chorionic gonadotropin human has been used:
- to induce oocyte maturation in cultured follicles
- along with pregnant mare serum gonadotropin (PMSG) to induce superovulation in mice
- as medium component for fetal testes culture to aid steroidogenic responsiveness
Vorbereitung Methode
CG is produced in the chorion.
Trademarks
A.P.L. (Ferring Pharmaceuticals); Follutein (Bristol-Myers Squibb); Pregnyl (Organon).
Allgemeine Beschreibung
Glycoprotein hormone consisting of a 92-amino acid α-chain which is identical to that of LH, FSH, and TSH; and a distinct 149-amino acid β-chain. Produced by chorionic tissue and responsible for maintaining the corpus luteum during early pregnancy. Also produced by trophoblast cell neoplasms, which are marked by elevated free hCG β-chains and hyperglycosylated hCG.
Biochem/physiol Actions
Elevated levels of hCG is observed in trophoblastic cancer. hCG levels are indicators of pregnancy and β subunit is majorly present in urine samples. hCG isoform detection is useful in the diagnosis and management of trophoblastic related diseases including carcinomas.
Clinical Use
Choriogonadotropin alfa is obtained by rDNA technology and is biologically and chemically identical to hCG of natural origin. It is used, like hCG of natural origin, for inducing ovulation in women with anovulatory infertility. Following proper pretreatment with a GnRH antagonist or superagonist to desensitize the pituitary, women participating in ART are treated with a folliclestimulating agent (e.g., menotropins) to effect the final maturation of the follicles within the ovaries. Ultrasonograms are used to determine proper follicle maturation before the administration of choriogonadotropin alfa to induce ovulation. A distinct advantage of this product is that it can be self-administered by the patient via SC injection.
Veterinary Drugs and Treatments
The veterinary product’s labeled indication is for “parenteral use in cows for the treatment of nymphomania (frequent or constant heat) due to cystic ovaries.” It has been used for other purposes in several species; refer to the Dosage section for more information.

Chorionic Gonadotropin Upstream-Materialien And Downstream Produkte

Gonadotropin, chorionisch Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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