Benzene,1,3,5-trimethyl-2-[(4-methylphenyl)sulfonyl]-

Benzene,1,3,5-trimethyl-2-[(4-methylphenyl)sulfonyl]- Chemische Eigenschaften,Einsatz,Produktion Methoden

• Verwenden

  ESI-05 has been used to study the effect of protein exchange directly activated by cAMP 2 on traumatic brain injury.

• Biochem/physiol Actions

  ESI-05 is a selective inhibitor against cAMP-regulated guanine nucleotide exhange factor (GEF) EPAC2 (Exchange factor directly activated by cAMP 2) activation by targeting an EPAC2-specific allosteric site at the interface of the two cAMP-binding domains. ESI-05 inhibits EAPC2, but not EPAC1 or PKA, activation by cAMP in a highly potent (IC50 = 430 nM; 25 μM cAMP) and cAMP-competitive manner in cell-free assays, and suppresses cAMP analog 007-AM-induced cellular Rap1 activation in EPAC2-, but not EPAC1-, expressing HEK293 transfectants.

• Lager

  Store at RT

Benzene,1,3,5-trimethyl-2-[(4-methylphenyl)sulfonyl]- Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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