CP-465022 (maleate)

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Warnung

• Gefahrenhinweise

  H302：Gesundheitsschädlich bei Verschlucken.

• Sicherheit

  P264：Nach Gebrauch gründlich waschen.

  P264：Nach Gebrauch gründlich waschen.

  P270：Bei Gebrauch nicht essen, trinken oder rauchen.

  P301+P312：BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.

  P330：Mund ausspülen.

  P501：Inhalt/Behälter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.

CP-465022 (maleate) Chemische Eigenschaften,Einsatz,Produktion Methoden

• Biologische Aktivität

  cp-465022 is an ampa antagonist.the inhibition of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (ampa) receptor has been hypothesized to lead to neuroprotective efficacy after cerebral ischemia on the basis of the activity in ischemia models of a variety of compounds with varying selectivity for ampa over other glutamate receptor subtypes.

• in vitro

  cp-465022 inhibited ampa receptor-mediated currents in rat cortical neurons and such inhibition was found to be noncompetitive with agonist concentration. cp-465022 was selective for ampa over kainate and n-methyl-d-aspartate receptors. however, cp-465022 was found to be equipotent for ampa receptors composed of different ampa receptor subunit combinations, which indicated that cp-465022 is equivalently potent for inhibition of ampa receptor-mediated responses in different types of neurons expressing different ampa receptor subunits [1].

• in vivo

  animal study showed that cp-465022 could potently and efficaciously inhibit ampa receptor-mediated hippocampal synaptic transmission and the induction of seizures. however, at comparable doses, cp-465022 failed to prevent ca1 neuron loss after brief global ischemia or to reduce infarct volume after temporary middle cerebral artery occlusion [2].

• IC 50

  25 nm for ampa receptor-mediated currents in rat cortical neurons

• Einzelnachweise

  [1] lazzaro jt, paternain av, lerma j, chenard bl, ewing fe, huang j, welch wm, ganong ah, menniti fs. functional characterization of cp-465,022, a selective, noncompetitive ampa receptor antagonist. neuropharmacology. 2002 feb;42(2):143-53.
  [2] menniti fs, buchan am, chenard bl, critchett dj, ganong ah, guanowsky v, seymour pa, welch wm. cp-465,022, a selective noncompetitive ampa receptor antagonist, blocks ampa receptors but is not neuroprotective in vivo. stroke. 2003 jan;34(1):171-6.

CP-465022 (maleate) Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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