Calciumdi(acetat)

Bezeichnung:Calciumdi(acetat)

CAS-Nr62-54-4

Englisch Name:Calcium acetate

CBNumberCB8312095

SummenformelC4H6CaO4

Molgewicht158.17

MOL-Datei62-54-4.mol

Synonyma

Calciumdi(acetat)

Essigsäure, Calciumsalz

Calciumdi(acetat) physikalisch-chemischer Eigenschaften

Schmelzpunkt	160°C (dec.)
Dichte	1,5 g/cm³
Brechungsindex	1.5500
FEMA	2228 \| CALCIUM ACETATE
Flammpunkt	160°C
storage temp.	Hygroscopic, Room Temperature, under inert atmosphere
Löslichkeit	H₂O: 1 M at 20 °C, clear, colorless
Aggregatzustand	Powder
Farbe	white
Wichte	1.50
PH	8(1 mM solution);8.43(10 mM solution);8.77(100 mM solution);9.13(1000 mM solution)
Geruch (Odor)	mild acetic
Geruchsart	acetic
Wasserlöslichkeit	soluble
Decomposition	160 ºC
Stabilität	Stable. Non-flammable. Incompatible with strong oxidizing agents.
InChIKey	VSGNNIFQASZAOI-UHFFFAOYSA-L
LogP	-0.29
CAS Datenbank	62-54-4(CAS DataBase Reference)
EPA chemische Informationen	Calcium acetate (62-54-4)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	26-36
WGK Germany	1
RTECS-Nr.	AF7525000
TSCA	Yes
HS Code	29152990
Giftige Stoffe Daten	62-54-4(Hazardous Substances Data)

Gefahreninformationscode (GHS)

Calcium acetate Chemische Eigenschaften,Einsatz,Produktion Methoden

ERSCHEINUNGSBILD
WEISSE BIS BRAUNEODER GRAUE KRISTALLE MIT CHARAKTERISTISCHEM GERUCH.
CHEMISCHE GEFAHREN
Zersetzung beim Erhitzen über 160°C unter Bildung von Acetondämpfen und Calciumcarbonat. Reagiert sehr heftig mit starken Säuren unter Bildung vonEssigsäurerauchen.
ARBEITSPLATZGRENZWERTE
TLV nicht festgelegt (ACGIH 2005).
MAK nicht festgelegt (DFG 2005).
AUFNAHMEWEGE
Aufnahme in den Körper durch Inhalation und durch Verschlucken.
INHALATIONSGEFAHREN
Eine belästigende Partikelkonzentration in der Luft kann beim Dispergieren schnell erreicht werden.
WIRKUNGEN BEI KURZZEITEXPOSITION
WIRKUNGEN BEI KURZZEITEXPOSITION:
Die Substanz reizt die Augen, die Haut und die Atemwege.
LECKAGE
Verschüttetes Material in Behältern sammeln. Reste mit viel Wasser wegspülen. Persönliche Schutzausrüstung: Atemschutzgerät, P1-Filter für inerte Partikel.
R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
Calcium acetate is a chemical compound which is calcium salt of acetic acid. It has the formula Ca(C₂H₃O₂)₂. Its standard name is calcium acetate, while calcium ethanoate is the systematic name. An older name is acetate of lime. The anhydrous form is very hygroscopic; therefore the monohydrate (Ca(CH₃COO)₂?H₂O) is the common form.
Chemische Eigenschaften
Calcium acetate occurs as a white or almost white, odorless or almost odorless, hygroscopic powder.
Verwenden
Calcium Acetate is the calcium salt of acetic acid which functions as a sequestrant and mold control agent. it contains approximately 25% calcium. it is a white odorless powder which is readily soluble in water with a solubility of approximately 37 g in 100 g water at 0°c. its solubility decreases with increasing temperature, with a sol- ubility of approximately 29 g in 100 g of water at 100°c.
Verwenden
Calcium Acetate is a salt of acetic acid (A167640), a common chemical reagent used in a multitude of organic reactions. It is the primary constituent of vinegar, contributing to its distinct taste and odor. It is used in the synthesis of dye-sensitized solar cells.
Verwenden
Calcium Acetate is the salt of acetic acid which is used as a preservative and sequestrant.
Vorbereitung Methode
Calcium acetate can be prepared by soaking calcium carbonate (found in eggshells, or in common carbonate rocks such as lime stone or marble) in vinegar:
CaCO₃ + 2CH₃COOH → Ca(CH₃COO)₂ + H2O + CO₂
Since both reagents would have been available pre-historically, the chemical would have been observable as crystals then.
synthetische
Produced by calcium hydroxide neutralization of acetic acid.
Definition
ChEBI: The calcium salt of acetic acid. It is used, commonly as a hydrate, to treat hyperphosphataemia (excess phosphate in the blood) in patients with kidney disease: the calcium ion combines with dietary phosphate to form (insoluble) calcium phosphate, which is excreted in the faeces.
Allgemeine Beschreibung
Calcium Acetate belongs to the group of calcium salts, widely used as phosphorus binders in patients with chronic renal failure.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Pharmazeutische Anwendungen
Calcium acetate is used as a preservative in oral and topical formulations.
Therapeutically, parenteral calcium acetate acts as a source of calcium ions for hypocalcemia or electrolyte balance. Oral calcium acetate is used as a complexing agent for hyperphosphatemia in dialysis patients. Calcium acetate is also used in the food industry as a stabilizer, buffer and sequestrant.
Clinical Use
Phosphate binding agent
Sicherheitsprofil
Poison by intravenous and intraperitoneal routes. Mutation data reported. See also CALCIUM COMPOUNDS. When heated to decomposition it emits acrid smoke and fumes.
Sicherheit(Safety)
Calcium acetate is used in oral and topical formulations. The pure form of calcium acetate is toxic by IP and IV routes.
LD₅₀ (mouse, IP): 0.075 g/kg
LD₅₀ (mouse, IV): 0.052 g/kg
LD₅₀ (rat, oral): 4.28 g/kg
Veterinary Drugs and Treatments
Calcium acetate can be used for oral administration to treat hyperphosphatemia in patients with chronic renal failure. Secondary to its phosphorus binding efficiency and lower concentration of elemental calcium, calcium acetate is considered the most effective and having the lowest potential for causing hypercalcemia of the calcium-based phosphorus-binding agents. When compared to calcium carbonate, calcium acetate binds approximately twice as much phosphorus per gram of elemental calcium administered. Unlike calcium citrate, calcium acetate does not promote aluminum absorption.
Arzneimittelwechselwirkung
Potentially hazardous interactions with other drugs
Can impair absorption of some drugs, e.g. iron, ciprofloxacin.
Stoffwechsel
The residual acetate will be metabolised through bicarbonate, which will be further excreted via normal metabolic routes. Any unbound calcium not involved in the binding of phosphate will be variable and may be absorbed. Calcium is absorbed mainly from the small intestine by active transport and passive diffusion. About one-third of ingested calcium is absorbed although this can vary depending upon dietary factors and the state of the small intestine. 1,25-Dihydroxycholecalciferol (calcitriol), a metabolite of vitamin D, enhances the active phase of absorption. Excess calcium is mainly excreted renally. Unabsorbed calcium is eliminated in the faeces, together with that secreted in the bile and pancreatic juice. Minor amounts are lost in the sweat, skin, hair, and nails.
Lager
Calcium acetate is stable although very hygroscopic, and so the monohydrate is the common form. It decomposes on heating (above 1608℃) to form calcium carbonate and acetone.
Store in well-closed airtight containers.
läuterung methode
Recrystallise it from water (3mL/g) by partial evaporation in a desiccator. [Beilstein 2 IV 113.]
Inkompatibilitäten
Calcium acetate is incompatible with strong oxidizing agents and moisture.
Regulatory Status
GRAS listed. Accepted for use as a food additive in Europe. Included in the FDA Inactive Ingredients Database (oral suspensions and tablets; topical emulsions, lotions, and creams). Included in nonparenteral medicines (oral tablets) licensed in the UK.

Calcium acetate Upstream-Materialien And Downstream Produkte

Calciumdi(acetat) Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

62-54-4, Calcium acetate Verwandte Suche:

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