p-Nitrobenzyl 2-Diazo-3-trimethylsilyloxy-3-butenoate

p-Nitrobenzyl 2-Diazo-3-trimethylsilyloxy-3-butenoate Chemische Eigenschaften,Einsatz,Produktion Methoden

• Verwenden

  4-Nitrobenzyl 2-Diazo-3-(trimethylsilyloxy)-3-butenoate is a useful research chemical compound used in the preparation and synthesis of (±)??-??asparenomycin C.

• Synthese

  p-Nitrobenzyl 2-Diazo-3-trimethylsilyloxy-3-butenoate is prepared by silylation of the corresponding diazoacetoacetate with a silyl triflate (Trimethylsilyl Trifluoromethanesulfonate or t-Butyldimethylsilyl Trifluoromethanesulfonate) and Triethylamine in CH2Cl2. For large scale preparations the use of Chlorotrimethylsilane, Potassium Iodide (one equivalent), and Et3N in acetonitrile is more advantageous.

• Lager

  Should be stored in solution in a dry, dark, cold place. The solid form is stable for several months in the refrigerator. The solid reagent is not shock sensitive but exothermic decomposition takes place on melting, generating 200 cal g-1 (138 cal g-1 for the TBDMS ether). Decomposition can also be initiated by metallic impurities (Cu, Rh, etc.).

p-Nitrobenzyl 2-Diazo-3-trimethylsilyloxy-3-butenoate Upstream-Materialien And Downstream Produkte

p-Nitrobenzyl 2-Diazo-3-trimethylsilyloxy-3-butenoate Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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