CYM50179

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Achtung

• Gefahrenhinweise

  H301：Giftig bei Verschlucken.

  H318：Verursacht schwere Augenschäden.

  H413：Kann für Wasserorganismen schädlich sein, mit langfristiger Wirkung.

• Sicherheit

  P280：Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.

  P301+P310：BEI VERSCHLUCKEN: Sofort GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.

  P305+P351+P338：BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

CYM50179 Chemische Eigenschaften,Einsatz,Produktion Methoden

• Verwenden

  ML-178 activates the S1P4 receptor, but is inactive against S1P1, S1P2, S1P3, and S1P5.

• Definition

  ChEBI: 2,6-dibromo-3-[2-(2,4-dichlorophenoxy)ethoxy]pyridine is a dichlorobenzene.

• Biologische Aktivität

  ml-178 is a novel and selective s1p4 activator with ec50 value of 46.3 nm [1].sphingosine-1-phosphate (s1p) is an extracellular lipid mediator released by activated blood platelets that serves to influence heart rate, coronary artery caliber, endothelial integrity, lung epithelial integrity and lymphocyte recirculation through five of the s1p receptors (s1p1/edg-1, s1p2/edg-5, s1p3/edg-3, s1p4/edg-6, and s1p5/edg-8). s1p4 receptor is coupled to gαi and gαo g proteins and activates erk, mapk and plc downstream pathways [1].ml-178 is a novel and selective s1p4 activator. ml178 activated s1p4 receptor with an ec50 of 46.3 nm, and is inactive against other members of the receptor family, with ec50s > 50 μm against s1p1, s1p2, s1p3, and s1p5 receptors. ml178 was inhibited by an s1p4 receptor-selective antagonist with an ic50 of 0.83 μm. ml178 was nontoxic to u2os cells with a cc50 of > 20 μm. ml178 was generally inactive against a broad array of off targets, including receptors, transporters, or ion channels [1].

• Einzelnachweise

  [1]. guerrero m, urbano m, velaparthi s, et al. probe development efforts to identify novel agonists of the sphingosine 1-phosphate receptor 4 (s1p4). probe reports from the nih molecular libraries program [internet]. bethesda (md): national center for biotechnology information (us); 2010-.2010 oct 12 [updated 2011 dec 12].

CYM50179 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global(19)Suppliers