Diphenylphosphinchlorid

Bezeichnung:Diphenylphosphinchlorid

CAS-Nr1499-21-4

Englisch Name:Diphenylphosphinic Chloride

CBNumberCB8273899

SummenformelC12H10ClOP

Molgewicht236.63

MOL-Datei1499-21-4.mol

Synonyma

Diphenylphosphinchlorid

Diphenylphosphinchlorid physikalisch-chemischer Eigenschaften

Schmelzpunkt	20°C
Siedepunkt	222 °C/16 mmHg (lit.)
Dichte	1.24 g/mL at 25 °C (lit.)
Brechungsindex	n20/D 1.609(lit.)
Flammpunkt	79 °F
storage temp.	2-8°C
Löslichkeit	soluble in Chloroform, methanol
Aggregatzustand	Liquid
Wichte	1.24
Farbe	Clear colorless to yellow
Wasserlöslichkeit	decomposes
Sensitive	Moisture Sensitive
BRN	975191
CAS Datenbank	1499-21-4(CAS DataBase Reference)
NIST chemische Informationen	Diphenylphosphinic chloride(1499-21-4)

Sicherheit

Kennzeichnung gefährlicher	C,F
R-Sätze:	10-34
S-Sätze:	16-26-36/37/39-45
RIDADR	UN 2920 8/PG 2
WGK Germany	3
F	10-21
Hazard Note	Flammable/Corrosive
HazardClass	8
PackingGroup	II
HS Code	29310095

Gefahreninformationscode (GHS)

Diphenylphosphinic Chloride Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R10:Entzündlich.
R34:Verursacht Verätzungen.
S-Sätze Betriebsanweisung:
S16:Von Zündquellen fernhalten - Nicht rauchen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
Chemische Eigenschaften
clear colorless to yellow liquid
Verwenden
Diphenylphosphinic chloride (Ph₂POCl) is widely used as a precursor to synthesize various chiral phosphine bidentate ligands for asymmetric synthesis, in addition to several peptide coupling agents.
Application
Diphenylphosphinic chloride is a reagent that is used in the synthesis of bidentate ligands and peptide coupling agents. It is used as flame retardants. It also act as pharmaceutical adjuvant.
reaction suitability
reaction type: Buchwald-Hartwig Cross Coupling Reaction
reaction type: Heck Reaction
reaction type: Hiyama Coupling
reaction type: Negishi Coupling
reaction type: Sonogashira Coupling
reaction type: Stille Coupling
reaction type: Suzuki-Miyaura Coupling
Synthese
To an oven-dried 100 mL, a two-necked flask fitted with a reflux condenser was added Et2O (depending on the Grignard reagent solution's concentration) and POCl3. The solution was cooled in an ice-salt mixture, and a Grignard reagent solution in Et2O was slowly added. After stirring with cooling for 30 min, the reaction mixture was brought to rt and stirred for the indicated time. The mixture was then cooled in an ice-salt mixture, and the alcohol and pyridine were slowly added. Stirring with cooling for 5 min was followed by reaction at rt. The reaction was quenched after the indicated time by cooling in an ice-salt mixture and adding sat aq NH4Cl. The crude mixture was then poured into CH2Cl2, washed three times with HCl, dried, filtered, and evaporated to dryness. The excess alcohol was removed using a short-path vacuum distillation apparatus, and the resulting crude product Diphenylphosphinic Chloride was purified by column chromatography.

Diphenylphosphinic Chloride Upstream-Materialien And Downstream Produkte

Diphenylphosphinchlorid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

1499-21-4, Diphenylphosphinic Chloride Verwandte Suche:

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